Biomaterials with suitable surface modification strategies are contributing significantly to the
rapid development of the field of bone tissue engineering. Despite these encouraging …

Osteal macrophages (OsteoMacs) are a special subtype of macrophage residing in bony
tissues. Interesting findings from basic research have pointed to their vast and substantial …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …

Osteoclasts are large multinucleated cells from hematopoietic origin and are responsible for
bone resorption. A balance between osteoclastic bone resorption and osteoblastic bone …

Implant surface properties are a key factor in bone responses to metallic bone implants. In
view of the emerging evidence on the important role of osteoclasts in bone regeneration, we …

The scaffold chemical composition and pore architecture are critical for successful bone
regeneration. Although the effects of chemical composition, micron-scale pores, and …

The success of scaffold‐based bone regeneration approaches strongly depends on the
performance of the biomaterial utilized. Within the efforts of regenerative medicine towards a …

Zinc-containing tricalcium phosphate (Zn-TCP) was synthesized to investigate the role of
zinc in osteoblastogenesis, osteoclastogenesis and in vivo bone induction in an ectopic …

A resorbable bone graft substitute should mimic native bone in its capacity to support bone
formation and be remodeled by osteoclasts (OCl) or other multinucleated cells such as …

The use of scaffolds with pores ranging from macroscale to nanoscale (ie, multiscale pores),
is an effective strategy to achieve favorable bone regeneration. Here, we report the …