Scorpions are well known for their dangerous stings that can result in severe consequences
for human beings, including death. Neurotoxins present in their venoms are responsible for …

Targeted therapy is considerably changing the treatment and prognosis of cancer.
Progressive understanding of the molecular mechanisms that regulate the establishment …

Rationale: We have previously found that T lymphocytes are essential for development of
angiotensin II–induced hypertension; however, the mechanisms responsible for T-cell …

Voltage-dependent potassium channels (Kv) are homotetramers composed of four voltage
sensors and one pore domain. Because of high-level structural flexibility, the first …

Large-conductance Ca2+-activated K+ channels facilitate the efflux of K+ ions from a variety
of cells and tissues following channel activation. It is now recognized that BK channels …

Voltage-gated potassium channel Kv1. 3 is an integral membrane protein, which is
selectively permeable for potassium ions and is activated upon a change of membrane …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

The large Ca2+-activated K+ channel (BK channel) reflects per excellence the dilemma of
the molecular target driven drug discovery process. Significant experimental evidence …

The large-conductance calcium-and voltage-activated K+ channel (BKCa) are encoded by
the Kcnma1 gene. They are ubiquitously expressed in neuronal, smooth muscle, astrocytes …

The potassium channel Kv1. 3 is an attractive pharmacological target for immunomodulation
of T cell-mediated autoimmune diseases. Potent and selective blockers of Kv1. 3 are …