The epigenome involves a complex set of cellular processes governing genomic activity.
Dissecting this complexity necessitates the development of tools capable of specifically …

Epigenome editing has rapidly evolved in recent years, with diverse applications that
include elucidating gene regulation mechanisms, annotating coding and noncoding …

Determining causal relationships between distinct chromatin features and gene expression,
and ultimately cell behavior, remains a major challenge. Recent developments in targetable …

CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 is a unique
genome editing tool that can be easily used in a wide range of applications, including …

Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor
evolution, but our understanding of ecDNA biology is limited. We determined the distribution …

The epigenome dynamically regulates gene expression and guides cellular differentiation
throughout the lifespan of eukaryotic organisms. Recent advances in clustered regularly …

The advancement in epigenetics research over the past several decades has led to the
potential application of epigenome-editing technologies for the treatment of various …

Alternative splicing allows expression of mRNA isoforms from a single gene, expanding the
diversity of the proteome. Its prevalence in normal biological and disease processes warrant …

Traditionally, it has been believed that inheritance is driven as phenotypic variations
resulting from changes in DNA sequence. However, this paradigm has been challenged and …

Drosophila has long been a premier model for the development and application of cutting-
edge genetic approaches. The CRISPR-Cas system now adds the ability to manipulate the …