Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …

The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Dysfunctional autophagy has been implicated in the pathogenesis of Alzheimer's disease
(AD). Previous evidence suggested disruptions of multiple stages of the autophagy …

Increasing evidence suggests that abnormal cerebral glucose metabolism is largely present
in Alzheimer's disease (AD). The brain utilizes glucose as its main energy source and a …

Alzheimer's disease (AD) is a complex neurodegenerative disease in the elderly and the
most common cause of human dementia. AD is characterized by accumulation of abnormal …

Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …

The autophagy–lysosomal pathway plays a critical role in intracellular clearance and
metabolic homeostasis. While neuronal autophagy is known to participate in the …

Abstract Alzheimer's disease (AD), characterized by the accumulation of protein aggregates
including phosphorylated Tau aggregates, is the most common neurodegenerative disorder …

Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis.
Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative …

Regulated cell death (RCD) is an ordered and tightly orchestrated set of changes/signaling
events in both gene expression and protein activity and is responsible for normal …