[HTML][HTML] The pharmacological properties of red grape polyphenol resveratrol: Clinical trials and obstacles in drug development

M Farhan, A Rizvi - Nutrients, 2023 - mdpi.com
Resveratrol is a stilbenoid from red grapes that possesses a strong antioxidant activity.
Resveratrol has been shown to have anticancer activity, making it a promising drug for the …

Nano-delivery systems for food bioactive compounds in cancer: Prevention, therapy, and clinical applications

IRS Vieira, CA Conte-Junior - Critical Reviews in Food Science …, 2024 - Taylor & Francis
Bioactive compounds represent a broad class of dietary metabolites derived from fruits and
vegetables, such as polyphenols, carotenoids and glucosinolates with potential for cancer …

[HTML][HTML] Combination therapy using polyphenols: An efficient way to improve antitumoral activity and reduce resistance

AF Vladu, D Ficai, AG Ene, A Ficai - International Journal of Molecular …, 2022 - mdpi.com
Polyphenols represent a structural class of mainly natural organic chemicals that contain
multiple phenol structural units. The beneficial properties of polyphenols have been …

[HTML][HTML] Intranasal administration of edaravone nanoparticles improves its stability and brain bioavailability

Y Lu, JTW Wang, N Li, X Zhu, Y Li, S Bansal… - Journal of Controlled …, 2023 - Elsevier
The clinical application of EDV, a potent antioxidant drug approved for amyotrophic lateral
sclerosis (ALS), is limited by its short biological half-life and poor water solubility …

Zein nanoparticles as low-cost, safe, and effective carriers to improve the oral bioavailability of resveratrol

R Nunes, A Baião, D Monteiro, J das Neves… - Drug delivery and …, 2020 - Springer
The clinical translation of the multiple pharmacological effects of resveratrol (RSV) found in
preclinical studies has been impaired by its poor bioavailability, due to poor solubility and …

[HTML][HTML] Nano-strategies targeting the integrin αvβ3 network for cancer therapy

TM Cheng, WJ Chang, HY Chu, R De Luca… - Cells, 2021 - mdpi.com
Integrin αvβ3, a cell surface receptor, participates in signaling transduction pathways in
cancer cell proliferation and metastasis. Several ligands bind to integrin αvβ3 to regulate …

Research progress on nanotechnology for delivery of active ingredients from traditional Chinese medicines

L Qiao, M Han, S Gao, X Shao, X Wang… - Journal of Materials …, 2020 - pubs.rsc.org
There is growing acceptance of traditional Chinese medicines (TCMs) as potential sources
of clinical agents based on the demonstrated efficacies of numerous bioactive compounds …

Resveratrol's anti-cancer effects through the modulation of tumor glucose metabolism

A Brockmueller, S Sameri, A Liskova, K Zhai… - Cancers, 2021 - mdpi.com
Simple Summary The prevention and treatment of cancer is an ongoing medical challenge.
In the context of personalized medicine, the well-studied polyphenol resveratrol could …

Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral bioavailability of resveratrol

T Vasconcelos, F Prezotti, F Araújo, C Lopes… - International Journal of …, 2021 - Elsevier
Resveratrol is a very promising anti-oxidant drug candidate with low oral bioavailability due
to its intrinsic poor water solubility, intestinal efflux and metabolization mechanisms …

Inulin-pluronic-stearic acid based double folded nanomicelles for pH-responsive delivery of resveratrol

AK Jangid, K Patel, P Jain, S Patel, N Gupta… - Carbohydrate …, 2020 - Elsevier
Herein, we introduce a novel amphiphilic bioconjugate (INU-F68-SA), synthesized by
functionalization of pluronic F68 with a polysaccharide inulin (INU) and a lipid stearic acid …