Tumor Therapy Strategies Based on Microenvironment‐Specific Responsive Nanomaterials

Z Zhang, C Ding, T Sun, L Wang… - Advanced Healthcare …, 2023‏ - Wiley Online Library
The tumor microenvironment (TME) is a complex and variable region characterized by
hypoxia, low pH, high redox status, overexpression of enzymes, and high‐adenosine …

Stimuli-responsive size-changeable strategy for cancer theranostics

G Cheng, D Wu, S Wang, X Zhang, P Yu, J Chang… - Nano Today, 2021‏ - Elsevier
It is essential to overcome many biological barriers and deliver theranostic agents to tumor
sites. As a basic property of nanoagents, particle size plays an important role in the whole …

[HTML][HTML] Controlled intracellular aggregation of magnetic particles improves permeation and retention for magnetic hyperthermia promotion and immune activation

A Hu, Y Pu, N Xu, Z Cai, R Sun, S Fu, R **, Y Guo… - Theranostics, 2023‏ - ncbi.nlm.nih.gov
Abstract Rationale: Magnetic nanoparticles (MNPs) are the most used inorganic
nanoparticles in clinics with therapeutic and imaging functions, but the inefficient magneto …

Macrophage-mediated delivery of magnetic nanoparticles for enhanced magnetic resonance imaging and magnetothermal therapy of solid tumors

F Xue, S Zhu, Q Tian, R Qin, Z Wang, G Huang… - Journal of Colloid and …, 2023‏ - Elsevier
Magnetothermal therapy (MHT) has attracted significant attention due to the advantages of
non-/minimal invasiveness, high efficiency, and excellent tissue penetration. However …

Peptide-based fluorescent Probes for the Diagnosis of Tumor and Image-Guided Surgery

MZ Cai, Z Wen, HZ Li, Y Yang, JX Liang, YS Liao… - Biosensors and …, 2025‏ - Elsevier
Fluorescent contrast agents are instrumental in amplifying signals, thereby enhancing the
sensitivity and accuracy of live optical imaging. However, a significant proportion of …

Tumor Diagnosis and Treatment Based on Stimuli‐Responsive Aggregation of Gold Nanoparticles

X Chang, H Wang, X Chen - Exploration, 2025‏ - Wiley Online Library
Gold nanomaterials have been used in the diagnosis and treatment of different tumors due
to their unique physical and chemical properties. Among them, gold nanoparticles with …

Construction of an AuHQ nano-sensitizer for enhanced radiotherapy efficacy through remolding tumor vasculature

X Wang, X Niu, X Zhang, Z Zhang, X Gao… - Journal of Materials …, 2021‏ - pubs.rsc.org
As a radiotherapy sensitizer, gold-based nanomaterials can significantly enhance
radiotherapy efficacy. However, the severe hypoxia and the low accumulation of …

Driving forces sorted in situ size‐increasing strategy for enhanced tumor imaging and therapy

Y Wang, W Zhen, X Jiang, J Li - Small Science, 2022‏ - Wiley Online Library
Nanoparticles (NPs) with diverse functionalities are widely used in tumor diagnostic and
therapeutic. However, the therapeutic efficiency is unsatisfactory because of the limited …

Construction of a pH/TGase “dual key”-responsive gold nano-radiosensitizer with liver tumor-targeting ability

Z Zhang, X Niu, X Feng, X Wang, L Yu… - ACS Biomaterials …, 2021‏ - ACS Publications
The method of tumor microenvironment (TME)-responsive aggregation has become a
promising approach to enhance treatment effect by improving the accumulation of …

[HTML][HTML] Stimuli-responsive self-regulating magnetic-thermal materials for selective magnetic hyperthermia therapy

X Wang, J Qin, Y Zhang, J Ma - OpenNano, 2022‏ - Elsevier
Magnetic hyperthermia therapy (MHT) has become an emerging research hotspot in tumor
hyperthermia with the superior tissue penetration of alternating magnetic fields. However …