Lipid and lipoprotein metabolism

KR Feingold - Endocrinology and Metabolism Clinics, 2022 - endo.theclinics.com
Lipids are insoluble in water and therefore cholesterol and triglycerides need to be
transported in association with proteins (ie, lipoproteins) in the bloodstream. Lipoproteins …

A modern approach to dyslipidemia

AJ Berberich, RA Hegele - Endocrine reviews, 2022 - academic.oup.com
Lipid disorders involving derangements in serum cholesterol, triglycerides, or both are
commonly encountered in clinical practice and often have implications for cardiovascular …

[HTML][HTML] Dyslipidemia management for primary prevention of cardiovascular events: Best in-clinic practices

N Thongtang, R Sukmawan, EJB Llanes… - Preventive Medicine …, 2022 - Elsevier
Dyslipidemia is a fundamental risk factor for cardiovascular diseases (CVDs) and can
worsen the prognosis, if unaddressed. Lipid guidelines are still evolving as dyslipidemia is …

[HTML][HTML] Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-b] Pyrrole Derivatives

MS Kamel, A Belal, MO Aboelez, EK Shokr… - Molecules, 2022 - mdpi.com
Novel pyrrolo [2, 3-b] pyrrole derivatives were synthesized and their hypolipidemic activity
was assessed in hyperlipidemic rats. The chemical structures of the new derivatives were …

Hypertriglyceridemia

A Chait - Endocrinology and Metabolism Clinics, 2022 - endo.theclinics.com
During the past several decades, the major focus on lipids has been on low-density
lipoproteins (LDL), largely as a result of LDL-lowering therapeutic advances that have led to …

Elevated plasma triglyceride concentration and risk of adverse clinical outcomes in 1.5 million people: a CALIBER linked electronic health record study

RS Patel, L Pasea, H Soran, P Downie, R Jones… - Cardiovascular …, 2022 - Springer
Background Assessing the spectrum of disease risk associated with hypertriglyceridemia is
needed to inform potential benefits from emerging triglyceride lowering treatments. We …

The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice

J Yin, J Wang, F Li, Z Yang, X Yang, W Sun, B **a… - Food & Function, 2019 - pubs.rsc.org
Hyperlipidemia is a major cause of atherosclerosis. Reverse cholesterol transport (RCT) is
believed to attenuate hyperlipidemia and the progression of atherosclerosis. Although …

Medium-, long-and medium-chain-type structured lipids ameliorate high-fat diet-induced atherosclerosis by regulating inflammation, adipogenesis, and gut microbiota …

C Yue, M Li, J Li, X Han, H Zhu, G Yu, J Cheng - Food & function, 2020 - pubs.rsc.org
Accumulating evidence has suggested that medium-, long-, and medium-chain (MLM)
structured lipids have anti-obesity effects, but whether they can alleviate the development of …

Polygenic architecture and cardiovascular risk of familial combined hyperlipidemia

M Trinder, D Vikulova, S Pimstone, GBJ Mancini… - Atherosclerosis, 2022 - Elsevier
Background and aims Familial combined hyperlipidemia (FCHL) is one of the most common
inherited lipid phenotypes, characterized by elevated plasma concentrations of …

Cardiovascular implications of metabolic dysfunction-associated fatty liver disease

Z Ren, A Wesselius, CDA Stehouwer… - Endocrinology and …, 2023 - endo.theclinics.com
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver
disease worldwide, with an estimated global prevalence of 32.4%. 1 Although a Division of …