Bradykinin receptor ligands: therapeutic perspectives
F Marceau, D Regoli - Nature reviews Drug discovery, 2004 - nature.com
Kinins, which are produced by the action of kallikrein enzymes, are blood-derived local-
acting peptides that have broad effects mediated by two related G-protein-coupled receptors …
acting peptides that have broad effects mediated by two related G-protein-coupled receptors …
Kinin B1 receptors: key G‐protein‐coupled receptors and their role in inflammatory and painful processes
Kinins are a family of peptides implicated in several pathophysiological events. Most of their
effects are likely mediated by the activation of two G‐protein‐coupled receptors: B1 and B2 …
effects are likely mediated by the activation of two G‐protein‐coupled receptors: B1 and B2 …
New topics in bradykinin research
To cite this article: Maurer M, Bader M, Bas M, Bossi F, Cicardi M, Cugno M, Howarth P,
Kaplan A, Kojda G, Leeb‐Lundberg F, Lötvall J, Magerl M. New topics in bradykinin …
Kaplan A, Kojda G, Leeb‐Lundberg F, Lötvall J, Magerl M. New topics in bradykinin …
Human plasma kallikrein-kinin system: physiological and biochemical parameters
JW Bryant, Z Shariat-Madar - Cardiovascular & Hematological …, 2009 - ingentaconnect.com
The plasma kallikrein-kinin system (KKS) plays a critical role in human physiology. The KKS
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …
encompasses coagulation factor XII (FXII), the complex of prekallikrein (PK) and high …
Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema
M Austinat, S Braeuninger, JB Pesquero, M Brede… - Stroke, 2009 - Am Heart Assoc
Background and Purpose—Brain edema is detrimental in ischemic stroke and its treatment
options are limited. Kinins are proinflammatory peptides that are released during tissue …
options are limited. Kinins are proinflammatory peptides that are released during tissue …
[PDF][PDF] Angiotensin‐converting‐enzyme 2 inhibits liver fibrosis in mice
The renin‐angiotensin system (RAS) plays a major role in liver fibrosis. Recently, a homolog
of angiotensin‐converting‐enzyme 1 (ACE1), termed ACE2, has been identified that …
of angiotensin‐converting‐enzyme 1 (ACE1), termed ACE2, has been identified that …
Kallikrein–kinin in stroke, cardiovascular and renal disease
J Chao, L Chao - Experimental physiology, 2005 - Wiley Online Library
Tissue kallikrein, a serine proteinase, produces the potent vasodilator kinin peptide from
kininogen substrate. The levels of tissue kallikrein are reduced in humans and animal …
kininogen substrate. The levels of tissue kallikrein are reduced in humans and animal …
Implication of the Kallikrein-Kinin system in neurological disorders: Quest for potential biomarkers and mechanisms
Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …
mortality worldwide. Despite a tremendous increase in our understanding of the …
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
M Kakoki, RW McGarrah, HS Kim… - Proceedings of the …, 2007 - National Acad Sciences
To explore the role of the kallikrein–kinin system in relation to ischemia/reperfusion injury in
the kidney, we generated mice lacking both the bradykinin B1 and B2 receptor genes …
the kidney, we generated mice lacking both the bradykinin B1 and B2 receptor genes …
Mechanisms of the anti‐inflammatory effects of the natural secosteroids physalins in a model of intestinal ischaemia and reperfusion injury
Reperfusion of an ischaemic tissue is associated with an intense inflammatory response and
inflammation‐mediated tissue injury. Physalins, a group of substances with secosteroidal …
inflammation‐mediated tissue injury. Physalins, a group of substances with secosteroidal …