Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging

K Jomova, R Raptova, SY Alomar, SH Alwasel… - Archives of …, 2023 - Springer
A physiological level of oxygen/nitrogen free radicals and non-radical reactive species
(collectively known as ROS/RNS) is termed oxidative eustress or “good stress” and is …

Several lines of antioxidant defense against oxidative stress: Antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight …

K Jomova, SY Alomar, SH Alwasel, E Nepovimova… - Archives of …, 2024 - Springer
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

[HTML][HTML] Selenium: an antioxidant with a critical role in anti-aging

G Bjørklund, M Shanaida, R Lysiuk, H Antonyak… - Molecules, 2022 - mdpi.com
Aging is characterized by an imbalance between damage inflicted by reactive oxygen
species (ROS) and the antioxidative defenses of the organism. As a significant nutritional …

Oxidative stress mitigation by antioxidants-an overview on their chemistry and influences on health status

AM Pisoschi, A Pop, F Iordache, L Stanca… - European Journal of …, 2021 - Elsevier
The present review paper focuses on the chemistry of oxidative stress mitigation by
antioxidants. Oxidative stress is understood as a lack of balance between the pro-oxidant …

[HTML][HTML] Exploring the potential of antioxidants from fruits and vegetables and strategies for their recovery

A Arias, G Feijoo, MT Moreira - Innovative food science & emerging …, 2022 - Elsevier
A balanced and nutritious diet is the cornerstone of good health. The nutritional pyramid
advises eating 5 servings of fruit and vegetables a day as a basic principle of a healthy diet …

[HTML][HTML] Natural products in drug discovery: advances and opportunities

AG Atanasov, SB Zotchev, VM Dirsch… - Nature reviews Drug …, 2021 - nature.com
Natural products and their structural analogues have historically made a major contribution
to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural …

Toxicology and pharmacology of synthetic organoselenium compounds: An update

CW Nogueira, NV Barbosa, JBT Rocha - Archives of Toxicology, 2021 - Springer
Here, we addressed the pharmacology and toxicology of synthetic organoselenium
compounds and some naturally occurring organoselenium amino acids. The use of …

Biomimetic diselenide‐bridged mesoporous organosilica nanoparticles as an X‐ray‐responsive biodegradable carrier for chemo‐immunotherapy

D Shao, F Zhang, F Chen, X Zheng, H Hu… - Advanced …, 2020 - Wiley Online Library
Chemotherapy causes off‐target toxicity and is often ineffective against solid tumors.
Targeted and on‐demand release of chemotherapeutics remains a challenge. Here, cancer …

Improving the metabolic fidelity of cancer models with a physiological cell culture medium

J Vande Voorde, T Ackermann, N Pfetzer… - Science …, 2019 - science.org
Currently available cell culture media may not reproduce the in vivo metabolic environment
of tumors. To demonstrate this, we compared the effects of a new physiological medium …

[HTML][HTML] Selenium as a bioactive micronutrient in the human diet and its cancer chemopreventive activity

D Radomska, R Czarnomysy, D Radomski… - Nutrients, 2021 - mdpi.com
This review answers the question of why selenium is such an important trace element in the
human diet. Daily dietary intake of selenium and its content in various food products is …