Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease

AR Bourgonje, M Feelisch, KN Faber, A Pasch… - Trends in molecular …, 2020 - cell.com
Inflammatory bowel disease (IBD) is associated with the production of reactive species that
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …

Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases

I Soufli, R Toumi, H Rafa… - World journal of …, 2016 - pmc.ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis are
complex disorders with undetermined etiology. Several hypotheses suggest that IBDs result …

Renal damage induced by cadmium and its possible therapy by mitochondrial transplantation

EY Hernández-Cruz, I Amador-Martínez… - Chemico-Biological …, 2022 - Elsevier
Cadmium (Cd) is one of the most toxic metals without biological function, and its
accumulation in living organisms has been reported. The kidney is a target organ in Cd …

Nitric oxide and peroxynitrite in health and disease

P Pacher, JS Beckman, L Liaudet - Physiological reviews, 2007 - journals.physiology.org
The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Protein carbonyl groups as biomarkers of oxidative stress

I Dalle-Donne, R Rossi, D Giustarini, A Milzani… - Clinica chimica acta, 2003 - Elsevier
Oxidative stress, an imbalance toward the pro-oxidant side of the pro-oxidant/antioxidant
homeostasis, occurs in several human diseases. Among these diseases are those in which …

Tannic acid and zinc ion coordination of nanase for the treatment of inflammatory bowel disease by promoting mucosal repair and removing reactive oxygen and …

C Zhang, Q Li, J **ng, Y Yang, M Zhu, L Lin, Y Yu… - Acta Biomaterialia, 2024 - Elsevier
Colon mucosal overexpression of reactive oxygen and nitrogen species (RONS) accelerates
the development of inflammatory bowel disease (IBD) and destroys the mucosa and its …

The role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases

A Piechota-Polanczyk, J Fichna - Naunyn-Schmiedeberg's archives of …, 2014 - Springer
In this review, we focus on the role of oxidative stress in the aetiology of inflammatory bowel
diseases (IBD) and colitis-associated colorectal cancer and discuss free radicals and free …

Endothelial mitochondrial oxidative stress determines podocyte depletion in segmental glomerulosclerosis

I Daehn, G Casalena, T Zhang, S Shi… - The Journal of clinical …, 2014 - jci.org
Focal segmental glomerular sclerosis (FSGS) is a primary kidney disease that is commonly
associated with proteinuria and progressive loss of glomerular function, leading to …

Effects of amino acid-derived luminal metabolites on the colonic epithelium and physiopathological consequences

F Blachier, F Mariotti, JF Huneau, D Tomé - Amino acids, 2007 - Springer
Depending on the amount of alimentary proteins, between 6 and 18 g nitrogenous material
per day enter the large intestine lumen through the ileocaecal junction. This material is used …

Ursolic acid: An anti‐and pro‐inflammatory triterpenoid

Y Ikeda, A Murakami, H Ohigashi - Molecular nutrition & food …, 2008 - Wiley Online Library
There is growing interest in the elucidation of the biological functions of triterpenoids,
ubiquitously distributed throughout the plant kingdom, some of which are used as anticancer …