Mitochondrial dynamics in health and disease: mechanisms and potential targets
W Chen, H Zhao, Y Li - Signal transduction and targeted therapy, 2023 - nature.com
Mitochondria are organelles that are able to adjust and respond to different stressors and
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
metabolic needs within a cell, showcasing their plasticity and dynamic nature. These …
Mitochondrial calcium exchange in physiology and disease
JF Garbincius, JW Elrod - Physiological reviews, 2022 - journals.physiology.org
The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …
fundamental biological process that has critical effects on cellular metabolism, signaling …
Structure and function of mitochondrial membrane protein complexes
W Kühlbrandt - BMC biology, 2015 - Springer
Biological energy conversion in mitochondria is carried out by the membrane protein
complexes of the respiratory chain and the mitochondrial ATP synthase in the inner …
complexes of the respiratory chain and the mitochondrial ATP synthase in the inner …
Mitochondrial machineries for protein import and assembly
Mitochondria are essential organelles with numerous functions in cellular metabolism and
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …
homeostasis. Most of the> 1,000 different mitochondrial proteins are synthesized as …
Emerging diversity in lipid–protein interactions
Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …
membrane environment for proteins to being embedded in to detailed roles in complicated …
Molecular mechanisms of mtDNA-mediated inflammation
A De Gaetano, K Solodka, G Zanini, V Selleri… - Cells, 2021 - mdpi.com
Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …
The role of mitochondria in reactive oxygen species generation and its implications for neurodegenerative diseases
S Kausar, F Wang, H Cui - Cells, 2018 - mdpi.com
Mitochondria are dynamic cellular organelles that consistently migrate, fuse, and divide to
modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen …
modulate their number, size, and shape. In addition, they produce ATP, reactive oxygen …
Mitochondria and Iron: current questions
BT Paul, DH Manz, FM Torti, SV Torti - Expert review of hematology, 2017 - Taylor & Francis
Introduction: Mitochondria are cellular organelles that perform numerous bioenergetic,
biosynthetic, and regulatory functions and play a central role in iron metabolism …
biosynthetic, and regulatory functions and play a central role in iron metabolism …
VDAC, a multi-functional mitochondrial protein regulating cell life and death
Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …
include functions well beyond the generation of cellular energy. It is now recognized that …
[HTML][HTML] Mitochondria in cancer
D Grasso, LX Zampieri, T Capelôa, JA Van de Velde… - Cell stress, 2020 - ncbi.nlm.nih.gov
The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …