The importance of cancer stem cells (CSCs) in tumor-initiation has been firmly established in
leukemia and recently reported for a variety of solid tumors. However, the role of CSCs in …

Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …

• Introduction• Functions of cancer progenitor cells in the cancer initiation and progression‐
New model of carcinogenesis based on the cancer progenitor cells‐Isolation and ex vitro …

Summary Polycomb Repressive Complexes (PRC1 and PRC2)-mediated epigenetic
regulation is critical for maintaining cellular homeostasis. Members of Polycomb Group …

This review summarizes the recent knowledge obtained on the molecular mechanisms
involved in the intrinsic and acquired resistance of cancer cells to current cancer therapies …

Normal somatic stem cells (SC) are naturally resistant to chemotherapeutic agents due to
their expression of various membrane transporter molecules (such as MDR-1), detoxifying …

It is well recognized that the majority of cancer related deaths is caused by metastatic
diseases. Therefore, there is an urgent need for the development of therapeutic intervention …

Metastasis remains the overwhelming cause of death for cancer patients. During metastasis,
cancer cells will leave the primary tumor, intravasate into the bloodstream, arrest at a distant …

First invoked by Paget, the seed and soil hypothesis suggests that the successful growth of
metastatic cells depends on the interactions and properties of cancer cells (seeds) and their …

Abstract Wilms' tumor (WT), the most frequent renal solid tumor in children, has been linked
to aberrant Wnt signaling. Herein, we demonstrate that different WTs can be grouped …