Many active pharmaceutical ingredients show low oral bioavailability due to factors such as
poor solubility and physical and chemical instability. The formation of inclusion complexes …

Sulfobutylether β-cyclodextrin (SBE-β-CD) is a polyanionic cyclic oligosaccharide that
contains glucopyranose units forming a torus ring-like structure. SBE-β-CD is gifted with …

Hot-melt extrusion (HME) is a globally recognized, robust, effective technology that
enhances the bioavailability of poorly soluble active pharmaceutical ingredients and offers …

The pharmaceutical industry has traditionally employed batch processing as a means of
synthesizing active pharmaceutical ingredients (APIs) on a commercial scale. Batch …

Despite numerous research efforts, drug delivery through the oral route remains a major
challenge to formulation scientists. The oral delivery of drugs poses a significant challenge …

Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-
soluble drugs. The escalating number of drugs with poor aqueous solubility, poor …

Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but
is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot …

Letrozole (LTZ) loaded dendrimeric nano-liposomes were prepared for targeted delivery to
breast cancer cells. Surface modification with cationic peptide dendrimers (PDs) and a …

Etodolac (ETD) is a non-steroidal anti-inflammatory drug (NSAID) given in rheumatoid
arthritis treatment. As it comes under BCS class II drug hence it exhibits low water solubility …

The poor aqueous solubility and/or permeability and thereby limited bioavailability largely
restricts the pharmaco-therapeutic implications of potent anticancer drugs such as …