The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties
resulting from the combination of chemoattractants and adhesion molecules. The soluble …

The chemokine system is a key player in the functioning of the immune system and a sought-
after target for drug candidates. The number of experimental structures of chemokines in …

G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating
guanine nucleotide exchange in the Gα subunit. To visualize this mechanism, we developed …

As the only member of the CX3C chemokine receptor subfamily, CX3CR1 binds to its sole
endogenous ligand CX3CL1, which shows notable potential as a therapeutic target in …

Receptor activity-modifying proteins (RAMPs) modulate the activity of many Family B
GPCRs. We show that RAMP2 directly interacts with the glucagon receptor (GCGR), a …

Herpesviruses are ancient large DNA viruses that have exploited gene capture as part of
their strategy to escape immune surveillance, promote virus spreading, or reprogram host …

CX3CL1, also named fractalkine or neurotactin, is the only known member of the CX3C
chemokine family that can chemoattract several immune cells. CX3CL1 exists in both …

AlphaFold and AlphaFold-Multimer have become two essential tools for the modeling of
unknown structures of proteins and protein complexes. In this work, we extensively …

Kaposi's sarcoma-associated herpesvirus (KSHV) encodes a viral G protein-coupled
receptor, KSHV-GPCR, that contributes to KSHV immune evasion and pathogenesis of …

Summary Hydroxycarboxylic acid receptor 3 (HCAR3), a class A G-protein-coupled receptor,
is an important cellular energy metabolism sensor with a key role in the regulation of …