Abstract Moorman, Antoon FM, and Vincent M. Christoffels. Cardiac Chamber Formation:
Development, Genes, and Evolution. Physiol Rev 83: 1223-1267, 2003; 10.1152/physrev …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

The ability to direct the differentiation of human pluripotent stem cells (hPSCs) to the different
cardiomyocyte subtypes is a prerequisite for modeling specific forms of cardiovascular …

Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific
gene networks results in birth defects, which affect 5% of live births. Congenital heart defects …

The sinoatrial node (SAN) is the primary pacemaker of the heart and controls heart rate
throughout life. Failure of SAN function due to congenital disease or aging results in slowing …

Although myocyte cell transplantation studies have suggested a promising therapeutic
potential for myocardial infarction, a major obstacle to the development of clinical therapies …

The embryonic vertebrate heart is divided into two major chambers, an anterior ventricle and
a posterior atrium. Although the fundamental differences between ventricular and atrial …

In this study we challenge the generally accepted view that cardiac chambers form from an
array of segmental primordia arranged along the anteroposterior axis of the linear and …

Forward-genetic analyses in Drosophila and Caenorhabditis elegans have given us
unprecedented insights into many developmental mechanisms. To study the formation of …

The mammalian heart is crafted from a few progenitor cells that are subject to rapidly
changing sets of instructions from their environment and from within. These instructions …