Survivin as a Therapeutic Target for the Treatment of Human Cancer

Q Wang, MI Greene - Cancers, 2024 - mdpi.com
Simple Summary Survivin is overexpressed in a wide variety of human cancers and is
associated with increased chemotherapy resistance, recurrence, and shorter patient …

Survivin in breast cancer: a review

MA Martínez-Sifuentes… - Genetic Testing and …, 2022 - liebertpub.com
Breast cancer is the most frequently diagnosed cancer in women and ranks second among
causes for cancer-related death in women. Gene technology has led to the recognition that …

Pan-cancer analysis identifies BIRC5 as a prognostic biomarker

A Fäldt Beding, P Larsson, K Helou, Z Einbeigi… - BMC cancer, 2022 - Springer
Background The BIRC5 gene encodes for the Survivin protein, which is a member of the
inhibitor of apoptosis family. Survivin is found in humans during fetal development, but …

Butein promotes ubiquitination-mediated survivin degradation inhibits tumor growth and overcomes chemoresistance

X Dong, W Liu, X Li, Y Gan, L Zhou, W Li, L **e - Scientific Reports, 2022 - nature.com
Overexpression of survivin is frequently observed in human malignancies and is associated
with poor prognosis. The present study found that survivin is highly expressed in …

S100A8/A9 predicts response to PIM kinase and PD-1/PD-L1 inhibition in triple-negative breast cancer mouse models

LR Begg, AM Orriols, M Zannikou, C Yeh… - Communications …, 2024 - nature.com
Background Understanding why some triple-negative breast cancer (TNBC) patients
respond poorly to existing therapies while others respond well remains a challenge. This …

[HTML][HTML] The prognostic and therapeutic implications of the chemoresistance gene BIRC5 in triple-negative breast cancer

GM Adinew, S Messeha, E Taka, KFA Soliman - Cancers, 2022 - mdpi.com
Simple Summary TNBC is the most aggressive type of breast cancer affecting women
worldwide, and chemoresistance poses a significant clinical challenge associated with a …

MRI-based breast cancer radiogenomics using RNA profiling: association with subtypes in a single-center prospective study

AY Park, MR Han, BK Seo, HY Ju, GS Son… - Breast Cancer …, 2023 - Springer
Background There are few prospective studies on the correlations between MRI features
and whole RNA-sequencing data in breast cancer according to molecular subtypes. The …

Interpretable deep learning methods for multiview learning

H Wang, H Lu, J Sun, SE Safo - BMC bioinformatics, 2024 - Springer
Background Technological advances have enabled the generation of unique and
complementary types of data or views (eg genomics, proteomics, metabolomics) and …

miR‐92a‐3p promotes breast cancer proliferation by regulating the KLF2/BIRC5 axis

ZH Yu, ZH Chen, GL Zhou, XJ Zhou, HY Ma… - Thoracic …, 2022 - Wiley Online Library
Background Breast cancer remains the most common malignancy in females around the
world. Recently, a growing number of studies have focused on gene dysregulation. In our …

Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules

C Martins-Gomes, FM Nunes, AM Silva - International Journal of …, 2023 - mdpi.com
Natural products used for their health-promoting properties have accompanied the evolution
of humanity. Nowadays, as an effort to scientifically validate the health-promoting effects …