Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Nucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-
binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Inflammasomes are cytoplasmic multiprotein complexes comprising a sensor protein,
inflammatory caspases, and in some but not all cases an adapter protein connecting the two …

INTRODUCTION The toxicity of high-dose ionizing radiation is associated with the induction
of both chronic and acute radiation syndromes that occur after partial or total body radiation …

Inflammation-associated insulin resistance is a key trigger of gestational diabetes mellitus
(GDM), but the underlying mechanisms and effective interventions remain unclear. Here, we …

NLRs constitute a large, highly conserved family of cytosolic pattern recognition receptors
that are central to health and disease, making them key therapeutic targets. NLRC5 is an …

Inflammasomes are molecular platforms that assemble upon sensing various intracellular
stimuli. Inflammasome assembly leads to activation of caspase 1, thereby promoting the …

The gut microbiota changes with age, but it is not clear to what degree these changes are
due to physiologic changes, age-associated inflammation or immunosenescence, diet …

The gut microbiota has been linked to the development of obesity and type 2 diabetes (T2D).
The underlying mechanisms as to how intestinal microbiota may contribute to T2D are only …