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[HTML][HTML] ABCB1 and ABCG2 regulation at the blood-brain barrier: potential new targets to improve brain drug delivery
The drug efflux transporters ABCB1 and ABCG2 at the blood-brain barrier limit the delivery
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …
of drugs into the brain. Strategies to overcome ABCB1/ABCG2 have been largely …
ABC transporters at the blood–brain interfaces, their study models, and drug delivery implications in gliomas
Drug delivery into the brain is regulated by the blood–brain interfaces. The blood–brain
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …
barrier (BBB), the blood–cerebrospinal fluid barrier (BCSFB), and the blood–arachnoid …
Opioids and the blood-brain barrier: a dynamic interaction with consequences on drug disposition in brain
C Chaves, F Remiao, S Cisternino… - Current …, 2017 - benthamdirect.com
Background: Opioids are widely used in pain management, acting via opioid receptors
and/or Toll-like receptors (TLR) present at the central nervous system (CNS). At the blood …
and/or Toll-like receptors (TLR) present at the central nervous system (CNS). At the blood …
The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse
Opioids are currently the primary treatment method used to manage both acute and chronic
pain. In the past two to three decades, there has been a surge in the use, abuse and misuse …
pain. In the past two to three decades, there has been a surge in the use, abuse and misuse …
[HTML][HTML] Study models of drug–drug interactions involving p-glycoprotein: the potential benefit of p-glycoprotein modulation at the kidney and intestinal levels
P-glycoprotein (P-gp) is a crucial membrane transporter situated on the cell's apical surface,
being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are …
being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are …
[HTML][HTML] The impact of P-glycoprotein on opioid analgesics: what's the real meaning in pain management and palliative care?
Opioids are widely used in cancer and non-cancer pain management. However, many
transporters at the blood–brain barrier (BBB), such as P-glycoprotein (P-gp, ABCB1/MDR1) …
transporters at the blood–brain barrier (BBB), such as P-glycoprotein (P-gp, ABCB1/MDR1) …
Opioid and neuroHIV comorbidity–current and future perspectives
With the current national opioid crisis, it is critical to examine the mechanisms underlying
pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in …
pathophysiologic interactions between human immunodeficiency virus (HIV) and opioids in …
[HTML][HTML] An interspecies molecular and functional study of organic cation transporters at the blood-brain barrier: from rodents to humans
Organic cation transporters (OCTs) participate in the handling of compounds in kidneys and
at the synaptic cleft. Their role at the blood-brain barrier (BBB) in brain drug delivery is still …
at the synaptic cleft. Their role at the blood-brain barrier (BBB) in brain drug delivery is still …
[HTML][HTML] High-dose acetaminophen alters the integrity of the blood–brain barrier and leads to increased CNS uptake of codeine in rats
The consumption of acetaminophen (APAP) can induce neurological changes in human
subjects; however, effects of APAP on blood–brain barrier (BBB) integrity are unknown. BBB …
subjects; however, effects of APAP on blood–brain barrier (BBB) integrity are unknown. BBB …
[HTML][HTML] Characterization of the blood–brain barrier integrity and the brain transport of SN-38 in an orthotopic xenograft rat model of diffuse intrinsic pontine glioma
The blood–brain barrier (BBB) hinders the brain delivery of many anticancer drugs. In
pediatric patients, diffuse intrinsic pontine glioma (DIPG) represents the main cause of brain …
pediatric patients, diffuse intrinsic pontine glioma (DIPG) represents the main cause of brain …