Understanding protein non-folding
This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
Flexible nets: the roles of intrinsic disorder in protein interaction networks
Proteins participate in complex sets of interactions that represent the mechanistic foundation
for much of the physiology and function of the cell. These protein–protein interactions are …
for much of the physiology and function of the cell. These protein–protein interactions are …
[HTML][HTML] α-Synuclein misfolding and Parkinson's disease
Substantial evidence links α-synuclein, a small highly conserved presynaptic protein with
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …
unknown function, to both familial and sporadic Parkinson's disease (PD). α-Synuclein has …
iLearn: an integrated platform and meta-learner for feature engineering, machine-learning analysis and modeling of DNA, RNA and protein sequence data
With the explosive growth of biological sequences generated in the post-genomic era, one
of the most challenging problems in bioinformatics and computational biology is to …
of the most challenging problems in bioinformatics and computational biology is to …
[HTML][HTML] WNK kinases sense molecular crowding and rescue cell volume via phase separation
When challenged by hypertonicity, dehydrated cells must recover their volume to survive.
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …
This process requires the phosphorylation-dependent regulation of SLC12 cation chloride …
Length-dependent prediction of protein intrinsic disorder
Background Due to the functional importance of intrinsically disordered proteins or protein
regions, prediction of intrinsic protein disorder from amino acid sequence has become an …
regions, prediction of intrinsic protein disorder from amino acid sequence has become an …
Rapid prediction and analysis of protein intrinsic disorder
Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous
physiological and pathological processes. Computational methods play an important role in …
physiological and pathological processes. Computational methods play an important role in …
Intrinsic disorder in transcription factors
Intrinsic disorder (ID) is highly abundant in eukaryotes, which reflect the greater need for
disorder-associated signaling and transcriptional regulation in nucleated cells. Although …
disorder-associated signaling and transcriptional regulation in nucleated cells. Although …
Physicochemical properties of cells and their effects on intrinsically disordered proteins (IDPs)
It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …
ESpritz: accurate and fast prediction of protein disorder
Motivation: Intrinsically disordered regions are key for the function of numerous proteins, and
the scant available experimental annotations suggest the existence of different disorder …
the scant available experimental annotations suggest the existence of different disorder …