Heart disease and stroke statistics—2019 update: a report from the American Heart Association

EJ Benjamin, P Muntner, A Alonso, MS Bittencourt… - Circulation, 2019 - ahajournals.org
Summary Each year, the American Heart Association (AHA), in conjunction with the National
Institutes of Health and other government agencies, brings together in a single document the …

Genetics of thoracic and abdominal aortic diseases: aneurysms, dissections, and ruptures

A Pinard, GT Jones, DM Milewicz - Circulation research, 2019 - ahajournals.org
Dissections or ruptures of aortic aneurysms remain a leading cause of death in the
developed world, with the majority of deaths being preventable if individuals at risk are …

Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated

E Elhaik - Scientific reports, 2022 - nature.com
Abstract Principal Component Analysis (PCA) is a multivariate analysis that reduces the
complexity of datasets while preserving data covariance. The outcome can be visualized on …

Heart-brain connections: Phenotypic and genetic insights from magnetic resonance images

B Zhao, T Li, Z Fan, Y Yang, J Shu, X Yang, X Wang… - Science, 2023 - science.org
Cardiovascular health interacts with cognitive and mental health in complex ways, yet little is
known about the phenotypic and genetic links of heart-brain systems. We quantified heart …

Heart disease and stroke statistics—2020 update: a report from the American Heart Association

SS Virani, A Alonso, EJ Benjamin, MS Bittencourt… - Circulation, 2020 - ahajournals.org
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports on the most up-to-date statistics related to heart disease, stroke …

Heart disease and stroke statistics-2021 update: a report from the American Heart Association.

SS Virani, A Alonso, HJ Aparicio, EJ Benjamin… - Circulation, 2021 - europepmc.org
Background The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …

Deep learning enables genetic analysis of the human thoracic aorta

JP Pirruccello, MD Chaffin, EL Chou, SJ Fleming… - Nature …, 2022 - nature.com
Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of
sudden death. We trained a deep learning model to evaluate the dimensions of the …

Genetics and mechanisms of thoracic aortic disease

E Chou, JP Pirruccello, PT Ellinor… - Nature Reviews …, 2023 - nature.com
Aortic disease has many forms including aortic aneurysm and dissection, aortic coarctation
or abnormalities in aortic function, such as loss of aortic distensibility. Genetic analysis in …

[HTML][HTML] Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Genetics of intracranial aneurysms

S Zhou, PA Dion, GA Rouleau - Stroke, 2018 - ahajournals.org
2 Stroke March 2018 environmental, and stochastic risk factors. 9 A large population-based
heritability study estimated the heritability of SAH to be 41%(95% CI, 23.7%–55.5%) …