[HTML][HTML] Loss of epigenetic information as a cause of mammalian aging
All living things experience an increase in entropy, manifested as a loss of genetic and
epigenetic information. In yeast, epigenetic information is lost over time due to the …
epigenetic information. In yeast, epigenetic information is lost over time due to the …
[HTML][HTML] Proteogenomic characterization of endometrial carcinoma
We undertook a comprehensive proteogenomic characterization of 95 prospectively
collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This …
collected endometrial carcinomas, comprising 83 endometrioid and 12 serous tumors. This …
Hox dosage and morphological diversification during development and evolution
Hox genes encode for evolutionary conserved transcription factors that have long fascinated
biologists since the observation of the first homeotic transformations in flies. Hox genes are …
biologists since the observation of the first homeotic transformations in flies. Hox genes are …
To control or to be controlled? Dual roles of CDK2 in DNA damage and DNA damage response
Q Liu, J Gao, C Zhao, Y Guo, S Wang, F Shen, X **ng… - DNA repair, 2020 - Elsevier
Abstract CDK2 (cyclin-dependent kinase 2), a member of the CDK family, has been shown
to play a role in many cellular activities including cell cycle progression, apoptosis and …
to play a role in many cellular activities including cell cycle progression, apoptosis and …
Erosion of the epigenetic landscape and loss of cellular identity as a cause of aging in mammals
All living things experience entropy, manifested as a loss of inherited genetic and epigenetic
information over time. As budding yeast cells age, epigenetic changes result in a loss of cell …
information over time. As budding yeast cells age, epigenetic changes result in a loss of cell …
[HTML][HTML] Current state of knowledge of human DNA polymerase eta protein structure and disease-causing mutations
POLη, encoded by the POLH gene, is a crucial protein for replicating damaged DNA and the
most studied specialized translesion synthesis polymerases. Mutations in POLη are …
most studied specialized translesion synthesis polymerases. Mutations in POLη are …
Homologous recombination DNA repair gene RAD51, XRCC2 & XRCC3 polymorphisms and breast cancer risk in South Indian women
T Rajagopal, A Seshachalam, KK Rathnam, S Talluri… - PLoS …, 2022 - journals.plos.org
Background Homologous recombination repair (HRR) accurately repairs the DNA double-
strand breaks (DSBs) and is crucial for genome stability. Genetic polymorphisms in crucial …
strand breaks (DSBs) and is crucial for genome stability. Genetic polymorphisms in crucial …
Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum‐binding proteins in nucleotide excision repair
BC Feltes - Protein Science, 2021 - Wiley Online Library
The seven xeroderma pigmentosum proteins (XPps), XPA–XPG, coordinate the nucleotide
excision repair (NER) pathway, promoting the excision of DNA lesions caused by exposition …
excision repair (NER) pathway, promoting the excision of DNA lesions caused by exposition …
Potential role of exitron‐containing homeobox genes in cancer
J de Faria Poloni, BC Feltes - WIREs Mechanisms of Disease, 2023 - Wiley Online Library
Homeobox genes are protagonists in developmental and cancer biology, making
comprehending their regulation pivotal in multiple molecular pathways. Exitrons, also known …
comprehending their regulation pivotal in multiple molecular pathways. Exitrons, also known …
Synthetic lethal gene pairs: Experimental approaches and predictive models
Synthetic lethality (SL) refers to a genetic interaction in which the simultaneous perturbation
of two genes leads to cell or organism death, whereas viability is maintained when only one …
of two genes leads to cell or organism death, whereas viability is maintained when only one …