Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …

Orexin‐A and orexin‐B, also named hypocretin‐1 and hypocretin‐2, are two hypothalamic
neuropeptides highly conserved across mammalian species. Their effects are mediated by …

Peptides promote the mitogenesis and migration of tumor cells, and cancer cells
overexpress peptide receptors. The involvement of the orexinergic system in cancer is …

Specific neurons in the lateral hypothalamus produce the orexin neuropeptides (orexin-A
and orexin-B). The orexin-peptides are transported to areas of the brain regulating sleep …

Orexin (hypocretin) receptor antagonists stand as a model for the development of targeted
CNS small-molecule therapeutics. The identification of mutations in the gene for the orexin 2 …

Narcolepsy is a rare, chronic neurological disease characterized by excessive daytime
sleepiness, cataplexy, vivid hallucinations, and sleep paralysis. Narcolepsy occurs in …

The orexin system consists of the peptide transmitters orexin-A and-B and the G protein-
coupled orexin receptors OX 1 and OX 2. Orexin receptors are capable of coupling to all four …

Large combinatorial libraries of N-substituted peptides would be an attractive source of
protein ligands, because these compounds are known to be conformationally constrained …

Combinatorial chemistry allows for the rapid synthesis of large compound libraries for high
throughput screenings in biology, medicinal chemistry, or materials science. Especially …

A library of 70 000 synthetically accessible azulene-based compounds was virtually
screened at the OX 2 receptor. Based on the results, a series of azulene derivatives was …