How to make a midbrain dopaminergic neuron
Midbrain dopaminergic (mDA) neuron development has been an intense area of research
during recent years. This is due in part to a growing interest in regenerative medicine and …
during recent years. This is due in part to a growing interest in regenerative medicine and …
Challenges and translational considerations of mesenchymal stem/stromal cell therapy for Parkinson's disease
Parkinson's disease (PD) is the second most common neurodegenerative disease
characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars …
characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars …
Embedded 3D printing in self‐healing annealable composites for precise patterning of functionally mature human neural constructs
Human in vitro models of neural tissue with tunable microenvironment and defined spatial
arrangement are needed to facilitate studies of brain development and disease. Towards …
arrangement are needed to facilitate studies of brain development and disease. Towards …
On-demand reversible UV-triggered interpenetrating polymer network-based drug delivery system using the Spiropyran–Merocyanine hydrophobicity switch
A reversible switchable on-demand UV-triggered drug delivery system (DDS) based on
interpenetrating polymer networks (IPNs) with silicone as the host polymer and spiropyran …
interpenetrating polymer networks (IPNs) with silicone as the host polymer and spiropyran …
Midbrain dopamine neurons in Parkinson׳ s disease exhibit a dysregulated miRNA and target-gene network
The degeneration of substantia nigra (SN) dopamine (DA) neurons in sporadic Parkinson׳ s
disease (PD) is characterized by disturbed gene expression networks. Micro (mi) RNAs are …
disease (PD) is characterized by disturbed gene expression networks. Micro (mi) RNAs are …
3D‐Printed soft lithography for complex compartmentalized microfluidic neural devices
Compartmentalized microfluidic platforms are an invaluable tool in neuroscience research.
However, harnessing the full potential of this technology remains hindered by the lack of a …
However, harnessing the full potential of this technology remains hindered by the lack of a …
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease
E Arenas - Journal of molecular cell biology, 2014 - academic.oup.com
Wnts are a highly conserved family of lipid-modified glycoproteins that work as morphogens
to activate several signaling pathways, leading to remodeling of the cytoskeleton and the …
to activate several signaling pathways, leading to remodeling of the cytoskeleton and the …
Pyrolysed 3D‐carbon scaffolds induce spontaneous differentiation of human neural stem cells and facilitate real‐time dopamine detection
Structurally patterned pyrolysed three‐dimensional carbon scaffolds (p3D‐carbon) are
fabricated and applied for differentiation of human neural stem cells (hNSCs) developed for …
fabricated and applied for differentiation of human neural stem cells (hNSCs) developed for …
In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition
M Lin, PM Mackie, F Shaerzadeh… - Acta neuropathologica …, 2021 - Springer
Pathophysiological changes in dopamine neurons precede their demise and contribute to
the early phases of Parkinson's disease (PD). Intracellular pathological inclusions of the …
the early phases of Parkinson's disease (PD). Intracellular pathological inclusions of the …
[HTML][HTML] Microglia-secreted factors enhance dopaminergic differentiation of tissue-and iPSC-derived human neural stem cells
Microglia have recently been established as key regulators of brain development. However,
their role in neuronal subtype specification remains largely unknown. Using three different …
their role in neuronal subtype specification remains largely unknown. Using three different …