Molecular mechanisms of dietary restriction promoting health and longevity

CL Green, DW Lamming, L Fontana - Nature Reviews Molecular Cell …, 2022 - nature.com
Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

[HTML][HTML] When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging

MM Mihaylova, A Chaix, M Delibegovic, JJ Ramsey… - Cell metabolism, 2023 - cell.com
An epidemic of obesity has affected large portions of the world, increasing the risk of
develo** many different age-associated diseases, including cancer, cardiovascular …

Electrosynthesis of α‐Amino Acids from NO and other NOx species over CoFe alloy‐decorated Self‐standing Carbon Fiber Membranes

J **an, S Li, H Su, P Liao, S Wang, R **ang… - Angewandte …, 2023 - Wiley Online Library
The conversion of industrial exhaust gases of nitrogen oxides into high‐value products is
significantly meaningful for global environment and human health. And green synthesis of …

Branched chain amino acids, aging and age-related health

DG Le Couteur, SM Solon-Biet, VC Cogger… - Ageing research …, 2020 - Elsevier
Branched chain amino acids (BCAA: leucine, valine, isoleucine) have key physiological
roles in the regulation of protein synthesis, metabolism, food intake and aging. Many studies …

[HTML][HTML] Impacts of essential amino acids on energy balance

F **ao, F Guo - Molecular metabolism, 2022 - Elsevier
Background Obesity develops due to an imbalance in energy homeostasis, wherein energy
intake exceeds energy expenditure. Accumulating evidence shows that manipulations of …

Physiological functions of threonine in animals: beyond nutrition metabolism

Q Tang, P Tan, N Ma, X Ma - Nutrients, 2021 - mdpi.com
Threonine (Thr), an essential amino acid for animals and the limiting amino acid in swine
and poultry diets, which plays a vital role in the modulation of nutritional metabolism …

FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice

CM Hill, DC Albarado, LG Coco, RA Spann… - Nature …, 2022 - nature.com
Dietary protein restriction is increasingly recognized as a unique approach to improve
metabolic health, and there is increasing interest in the mechanisms underlying this …

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk

X Zhang, D Kapoor, SJ Jeong, A Fappi, J Stitham… - Nature …, 2024 - nature.com
High protein intake is common in western societies and is often promoted as part of a
healthy lifestyle; however, amino-acid-mediated mammalian target of rapamycin (mTOR) …

[HTML][HTML] Amino acid metabolism, transport and signalling in the liver revisited

CC Paulusma, WH Lamers, S Broer… - Biochemical …, 2022 - Elsevier
The liver controls the systemic exposure of amino acids entering via the gastro-intestinal
tract. For most amino acids except branched chain amino acids, hepatic uptake is very …

[HTML][HTML] Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice

CL Green, ME Trautman, K Chaiyakul, R Jain, YH Alam… - Cell Metabolism, 2023 - cell.com
Low-protein diets promote health and longevity in diverse species. Restriction of the
branched-chain amino acids (BCAAs) leucine, isoleucine, and valine recapitulates many of …