The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …

Respiratory chain dysfunction plays an important role in human disease and aging. It is now
well established that the individual respiratory complexes can be organized into …

Mitochondrial dysfunction is a hallmark of multiple metabolic complications. Physical activity
is known to increase mitochondrial content in skeletal muscle, counteracting age-related …

Leber hereditary optic neuropathy (LHON) and autosomal-dominant optic atrophy (DOA) are
the two most common inherited optic neuropathies in the general population. Both disorders …

Mitochondria are highly dynamic, except in adult cardiomyocytes. Yet, the fission and fusion-
promoting proteins that mediate mitochondrial dynamism are highly expressed in, and …

The decade since the publication of the third edition of this volume has been an era of great
progress in biology in general and the plant sciences in particular. This is especially true …

INTRODUCTION During heart development, increased oxygenation during the early
perinatal period and a change in nutrient availability evokes a switch in mitochondrial …

The organization of individual respiratory Complexes I, III, and IV (mammalian cells) or III
and IV (yeast) of the mitochondria into higher order supercomplexes (SCs) is generally …

Mitochondrial oxidative phosphorylation (OXPHOS) sustains organelle function and plays a
central role in cellular energy metabolism. The OXPHOS system consists of 5 multisubunit …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …