Regulation of membrane protein structure and function by their lipid nano-environment
Transmembrane proteins comprise~ 30% of the mammalian proteome, mediating
metabolism, signalling, transport and many other functions required for cellular life. The …
metabolism, signalling, transport and many other functions required for cellular life. The …
Membrane lipid composition: effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues
D Casares, PV Escribá, CA Rosselló - International journal of molecular …, 2019 - mdpi.com
Biological membranes are key elements for the maintenance of cell architecture and
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …
physiology. Beyond a pure barrier separating the inner space of the cell from the outer, the …
Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape
A fundamental feature of cellular plasma membranes (PMs) is an asymmetric lipid
distribution between the bilayer leaflets. However, neither the detailed, comprehensive …
distribution between the bilayer leaflets. However, neither the detailed, comprehensive …
Lipid rafts: controversies resolved, mysteries remain
The lipid raft hypothesis postulates that lipid–lipid interactions can laterally organize
biological membranes into domains of distinct structures, compositions, and functions. This …
biological membranes into domains of distinct structures, compositions, and functions. This …
Membrane phase separation drives responsive assembly of receptor signaling domains
Plasma membrane heterogeneity has been tied to a litany of cellular functions and is often
explained by analogy to membrane phase separation; however, models based on phase …
explained by analogy to membrane phase separation; however, models based on phase …
Coupling of protein condensates to ordered lipid domains determines functional membrane organization
During T cell activation, the transmembrane adaptor protein LAT (linker for activation of T
cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has …
cells) forms biomolecular condensates with Grb2 and Sos1, facilitating signaling. LAT has …
Structural and functional consequences of reversible lipid asymmetry in living membranes
Maintenance of lipid asymmetry across the two leaflets of the plasma membrane (PM)
bilayer is a ubiquitous feature of eukaryotic cells. Loss of this asymmetry has been widely …
bilayer is a ubiquitous feature of eukaryotic cells. Loss of this asymmetry has been widely …
Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Regulation of transmembrane signaling by phase separation
Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …
initiate signal transduction in response to environmental cues. Extracellular ligand …
Membrane homeostasis beyond fluidity: control of membrane compressibility
Biomembranes are complex materials composed of lipids and proteins that
compartmentalize biochemistry. They are actively remodeled in response to physical and …
compartmentalize biochemistry. They are actively remodeled in response to physical and …