Conspectus Noncovalent DNA–protein interactions are at the heart of normal cell function. In
eukaryotic cells, genomic DNA is wrapped around histone octamers to allow for …

O 6-Alkylguanine-DNA alkyltransferase (AGT) is a widely distributed, unique DNA repair
protein that acts as a single agent to directly remove alkyl groups located on the O 6-position …

DNA alkylation or adduct formation occurs at nucleophilic sites in DNA, mainly the N7-
position of guanine. Ever since identification of the first N7-guanine adduct, several hundred …

Tremendous advances have been made in the study of biomarkers related to
carcinogenesis during the past 20 years. This perspective will briefly review improvements …

DNA–protein crosslinks (DPCs) are toxic DNA lesions wherein a protein is covalently
attached to DNA. If not rapidly repaired, DPCs create obstacles that disturb DNA replication …

DNA is constantly exposed to a wide array of genotoxic agents, generating a variety of forms
of DNA damage. DNA-protein crosslinks (DPCs)—the covalent linkage of proteins with a …

It has been 20 years since the publication of Chemistry of Protein Conjugation and Cross-
Linking. During this period, great advances have been made in the area of cross-linking of …

Methylglyoxal (MGO) is an electrophilic α-oxoaldehyde generated endogenously through
metabolism of carbohydrates and exogenously due to autoxidation of sugars, degradation of …

1, 2, 3, 4-Diepoxybutane (DEB) is a strongly genotoxic diepoxide hypothesized to be the
ultimate carcinogenic metabolite of the common industrial chemical and environmental …

The antitumor activity of chemotherapeutic nitrogen mustards including chlorambucil,
cyclophosphamide, and melphalan is commonly attributed to their ability to induce DNA …