CD4+ T cells are crucial for directing appropriate immune responses during host defense
and for the pathogenesis of inflammatory diseases. In addition to the classical biphasic …

This review covers basic aspects of histone modification and the role of posttranslational
histone modifications in the development of allergic diseases, including the immune …

Annotations of gene structures and regulatory elements can inform genome-wide
association studies (GWASs). However, choosing the relevant annotations for interpreting …

A characteristic feature of asthma is the aberrant accumulation, differentiation or function of
memory CD4+ T cells that produce type 2 cytokines (TH2 cells). By map** genome-wide …

Identifying genomic annotations that differentiate causal from trait-associated variants is
essential to fine map** disease loci. Although many studies have identified non-coding …

Asthma and autoimmune disease susceptibility has been strongly linked to genetic variants
in the 17q21 haploblock that alter the expression of ORMDL3; however, the molecular …

An estimated 300 million people currently suffer from asthma, which causes approximately
250 000 deaths a year. Allergen‐specific T‐helper (Th) cells produce cytokines that induce …

Unbiased genetic approaches, especially genome-wide association studies, have identified
novel genetic targets in the pathogenesis of asthma, but so far these targets account for only …

Graves disease (GD) is an autoimmune condition caused by interacting genetic and
environmental factors. Genetic studies have mapped several single-nucleotide …

Asthma is a chronic disease which causes recurrent breathlessness affecting 300 million
people worldwide of whom 250,000 die annually. The epigenome is a set of heritable …