Successful drug discovery is like finding oases of safety and efficacy in chemical and
biological deserts. Screens in disease models, and other decision tools used in drug …

Abstract Background Systematic Reviews (SRs) of experimental animal studies are not yet
common practice, but awareness of the merits of conducting such SRs is steadily increasing …

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

A study with low statistical power has a reduced chance of detecting a true effect, but it is
less well appreciated that low power also reduces the likelihood that a statistically significant …

Abstract The US National Institute of Neurological Disorders and Stroke convened major
stakeholders in June 2012 to discuss how to improve the methodological reporting of animal …

Recent systematic reviews and empirical evaluations of the cognitive sciences literature
suggest that publication and other reporting biases are prevalent across diverse domains of …

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Many advances have been achieved in terms of understanding the molecular and cellular
mechanisms of ischemic stroke. But thus far, clinically effective neuroprotectants remain …

Treatments for acute ischaemic stroke continue to evolve after the superior value of
endovascular thrombectomy was confirmed over systemic thrombolysis. Unfortunately …