A systematic review of potential long-term effects of sport-related concussion

G Manley, AJ Gardner, KJ Schneider… - British journal of sports …, 2017 - bjsm.bmj.com
Objective Systematic review of possible long-term effects of sports-related concussion in
retired athletes. Data sources Ten electronic databases. Study selection Original research; …

The neuropathology of traumatic brain injury

AC Mckee, DH Daneshvar - Handbook of clinical neurology, 2015 - Elsevier
Traumatic brain injury, a leading cause of mortality and morbidity, is divided into three
grades of severity: mild, moderate, and severe, based on the Glasgow Coma Scale, the loss …

Cumulative head impact exposure predicts later-life depression, apathy, executive dysfunction, and cognitive impairment in former high school and college football …

PH Montenigro, ML Alosco, BM Martin… - Journal of …, 2017 - liebertpub.com
The term “repetitive head impacts”(RHI) refers to the cumulative exposure to concussive and
subconcussive events. Although RHI are believed to increase risk for later-life neurological …

The spectrum of disease in chronic traumatic encephalopathy

AC McKee, TD Stein, CJ Nowinski, RA Stern… - Brain, 2013 - academic.oup.com
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as a consequence
of repetitive mild traumatic brain injury. We analysed post-mortem brains obtained from a …

Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports

P Shahim, H Zetterberg, Y Tegner, K Blennow - Neurology, 2017 - neurology.org
Objective: To evaluate whether the axonal protein neurofilament light (NFL) in serum is a
sensitive biomarker to detect subtle brain injury or concussion in contact sports athletes …

Long-term consequences of traumatic brain injury: current status of potential mechanisms of injury and neurological outcomes

HM Bramlett, WD Dietrich - Journal of neurotrauma, 2015 - liebertpub.com
Traumatic brain injury (TBI) is a significant clinical problem with few therapeutic interventions
successfully translated to the clinic. Increased importance on the progressive, long-term …

Military-related mild traumatic brain injury: clinical characteristics, advanced neuroimaging, and molecular mechanisms

SY Kim, PH Yeh, JM Ollinger, HD Morris… - Translational …, 2023 - nature.com
Mild traumatic brain injury (mTBI) is a significant health burden among military service
members. Although mTBI was once considered relatively benign compared to more severe …

Role of subconcussion in repetitive mild traumatic brain injury: a review

JE Bailes, AL Petraglia, BI Omalu, E Nauman… - Journal of …, 2013 - thejns.org
Research now suggests that head impacts commonly occur during contact sports in which
visible signs or symptoms of neurological dysfunction may not develop despite those …

Chronic neuropathologies of single and repetitive TBI: substrates of dementia?

DH Smith, VE Johnson, W Stewart - Nature Reviews Neurology, 2013 - nature.com
Traumatic brain injury (TBI) has long been recognized to be a risk factor for dementia. This
association has, however, only recently gained widespread attention through the increased …

Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood

H Zetterberg, DH Smith, K Blennow - Nature Reviews Neurology, 2013 - nature.com
Mild traumatic brain injury (TBI), which is defined as a head trauma resulting in a brief loss of
consciousness and/or alteration of mental state, is usually benign, but occasionally causes …