Research over the years has shown that causes of Alzheimer's disease are not well
understood, but over the past years, the involvement of epigenetic mechanisms in the …

Aging is characterized by functional decline in homeostatic regulation and vital cellular
events. This process can be linked with the development of cardiovascular diseases (CVDs) …

Importance Recent large-scale genome-wide association studies have discovered several
genetic variants associated with Alzheimer disease (AD); however, the extent to which DNA …

Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is
critical to identify novel blood-based DNA methylation biomarkers to better understand the …

Abstract Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, has emerged as a key
regulator of cellular processes linked to ageing and neurodegeneration. SIRT1 modulates …

Alzheimer's disease (AD) is a neurodegenerative disease mainly characterized by
progressive cognitive dysfunction and memory impairment. Recent studies have shown that …

Epigenetic alterations represent a sort of functional modifications related to the genome that
are not responsible for changes in the nucleotide sequence. DNA methylation is one of such …

Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ)
and loss of neurons. Recently, a growing body of evidences have indicated that as a herbal …

Physical exercise has become a potentially beneficial therapy for reducing
neurodegeneration symptoms in Alzheimer's disease. Previous studies have shown that …

Aim It is now clear that insulin signaling has important roles in regulation of neuronal
functions in the brain. Dysregulation of brain insulin signaling has been linked to …