Mycolic acids are major and specific lipid components of the mycobacterial cell envelope
and are essential for the survival of members of the genus Mycobacterium that contains the …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis are
urgently needed. We report on the identification of an adamantyl urea compound that shows …

Mycobacterium tuberculosis, which is the aetiological agent of tuberculosis, owes much of its
success as a pathogen to its unique cell wall and unusual mechanism of growth, which …

Mycobacteria are surrounded by a complex multilayered envelope and elongate at the
poles. The principles that organize the coordinated addition of chemically diverse cell wall …

Mycolic acids are very long‐chain fatty acids representing essential components of the
mycobacterial cell wall. Considering their importance, characterization of key enzymes …

Mycobacterium tuberculosis, the bacterium responsible for tuberculosis, is the global
leading cause of mortality from an infectious agent. Part of this success relies on the unique …

Control and manipulation of bacterial populations requires an understanding of the factors
that govern growth, division, and antibiotic action. Fluorescent and chemically reactive small …

Mycobacteria have a distinctive glycolipid-rich outer membrane, the mycomembrane, which
is a critical target for tuberculosis drug development. However, proteins that associate with …

Mycolate-containing compounds constitute major strategic elements of the protective coat
surrounding the tubercle bacillus. We have previously shown that FAAL32-Pks13 polyketide …