α1-Antitrypsin (AAT) is the archetype member of the serine protease inhibitor (SERPIN)
supergene family. The AAT deficiency is most often associated with the Z mutation, which …

Brain development is a sequential anatomical process characterised by specific well-
defined stages of growth and maturation. One of the fundamental and necessary events in …

The rationale of α1-antitrypsin (AAT) augmentation therapy to treat progressive emphysema
in AAT-deficient patients is based on inhibition of neutrophil elastase; however, the benefit of …

The identification of biomarkers to noninvasively detect prediabetes/diabetes will facilitate
interventions designed to prevent or delay progression to frank diabetes and its attendant …

Pathological inflammation and autoimmune disease frequently involve elevated neutrophil
activity in the absence of infectious agents. Tumor necrosis factor–α (TNF-α) contributes to …

Acute phase proteins (APPs) are a group of circulating plasma proteins which undergo
changes quantitatively or qualitatively at the time of inflammation. Many of these APPs are …

Several observations suggest endogenous suppressors of inflammatory mediators are
present in human blood. α-1-Antitrypsin (AAT) is the most abundant serine protease inhibitor …

Abstract α 1-Antitrypsin (AAT) is a 52-kDa circulating serine protease inhibitor. Production of
AAT by the liver maintains 0.9-1.75 mg/mL circulating levels. During acute-phase responses …

Human pancreatic islet transplantation offers diabetic patients tight glucose control but has
low graft survival rates. The immunosuppressive drugs that are administered to graft …

Chronic obstructive pulmonary disease (COPD) patients frequently suffer from multiple
comorbidities, resulting in poor outcomes for these patients. Diabetes is observed at a …