[HTML][HTML] Advances in the neurobiology of hearing disorders: recent developments regarding the basis of tinnitus and hyperacusis

M Knipper, P Van Dijk, I Nunes, L Rüttiger… - Progress in …, 2013 - Elsevier
The prevalence of hearing problems in the Western world has, due to aging of the
population, doubled over the past 30 years. Thereby, noise-induced hearing loss is an …

Genetics of tinnitus: an emerging area for molecular diagnosis and drug development

JA Lopez-Escamez, T Bibas, RFF Cima… - Frontiers in …, 2016 - frontiersin.org
Subjective tinnitus is the perception of sound in the absence of external or bodily-generated
sounds. Chronic tinnitus is a highly prevalent condition affecting over 70 million people in …

Chronic pain: lost inhibition?

LA Henderson, CC Peck, ET Petersen… - Journal of …, 2013 - jneurosci.org
Human brain imaging has revealed that acute pain results from activation of a network of
brain regions, including the somatosensory, insular, prefrontal, and cingulate cortices. In …

Single unit hyperactivity and bursting in the auditory thalamus of awake rats directly correlates with behavioural evidence of tinnitus

BI Kalappa, TJ Brozoski, JG Turner… - The Journal of …, 2014 - Wiley Online Library
Key points Medial geniculate body (MGB) single units recorded from sound‐exposed
animals with behavioural evidence of tinnitus exhibits enhanced spontaneous firing and …

Noise trauma-induced behavioral gap detection deficits correlate with reorganization of excitatory and inhibitory local circuits in the inferior colliculus and are …

JJ Sturm, YX Zhang-Hooks, H Roos, T Nguyen… - Journal of …, 2017 - jneurosci.org
Hearing loss leads to a host of cellular and synaptic changes in auditory brain areas that are
thought to give rise to auditory perception deficits such as temporal processing impairments …

[HTML][HTML] Tinnitus-related dissociation between cortical and subcortical neural activity in humans with mild to moderate sensorineural hearing loss

K Boyen, E de Kleine, P van Dijk, DRM Langers - Hearing research, 2014 - Elsevier
Tinnitus is a phantom sound percept that is strongly associated with peripheral hearing loss.
However, only a fraction of hearing-impaired subjects develops tinnitus. This may be based …

Too blind to see the elephant? Why neuroscientists ought to be interested in tinnitus

M Knipper, B Mazurek, P van Dijk… - Journal of the Association …, 2021 - Springer
A curative therapy for tinnitus currently does not exist. One may actually exist but cannot
currently be causally linked to tinnitus due to the lack of consistency of concepts about the …

Unilateral tinnitus: changes in connectivity and response lateralization measured with fMRI

CP Lanting, E de Kleine, DRM Langers, P van Dijk - PloS one, 2014 - journals.plos.org
Tinnitus is a percept of sound that is not related to an acoustic source outside the body. For
many forms of tinnitus, mechanisms in the central nervous system are believed to play a role …

Tinnitus and hyperacusis: Contributions of paraflocculus, reticular formation and stress

YC Chen, GD Chen, BD Auerbach, S Manohar… - Hearing research, 2017 - Elsevier
Tinnitus and hyperacusis are common and potentially serious hearing disorders associated
with noise-, age-or drug-induced hearing loss. Accumulating evidence suggests that tinnitus …

Tinnitus-related changes in the inferior colliculus

JI Berger, B Coomber - Frontiers in neurology, 2015 - frontiersin.org
Tinnitus is highly complex, diverse, and difficult to treat, in part due to the fact that the
underlying causes and mechanisms remain elusive. Tinnitus is generated within the …