In the last century, vaccination has been the most effective medical intervention to reduce
death and morbidity caused by infectious diseases. It is believed that vaccines save at least …

Many important interactions between bacterial pathogens and their hosts are highly specific
binding events that involve host or pathogen carbohydrate structures (glycans). Glycan …

Abstract Background In September 2015, the four-component, protein-based meningococcal
serogroup B vaccine (4CMenB; Bexsero) became available for private purchase in Spain …

Vaccines have a history that started late in the 18th century. From the late 19th century,
vaccines could be developed in the laboratory. However, in the 20th century, it became …

The new superbug Neisseria gonorrhoeae has retained resistance to antimicrobials
previously recommended for first-line treatment and has now demonstrated its capacity to …

The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …

Meningococcus, an obligate human bacterial pathogen, remains a worldwide and
devastating cause of epidemic meningitis and sepsis. However, advances have been made …

Personalized medicine is a broad and rapidly advancing field of health care that is informed
by each person's unique clinical, genetic, genomic, and environmental information …

Neisseria meningitidis is a major cause of endemic cases and epidemics of meningitis and
devastating septicemia. Although effective vaccines exist for several serogroups of …

As reviewed in this paper, meningococcal disease epidemiology varies substantially by
geographic area and time. The disease can occur as sporadic cases, outbreaks, and large …