Measuring DNA modifications with the comet assay: a compendium of protocols
A Collins, P Møller, G Gajski, S Vodenková… - Nature protocols, 2023 - nature.com
The comet assay is a versatile method to detect nuclear DNA damage in individual
eukaryotic cells, from yeast to human. The types of damage detected encompass DNA …
eukaryotic cells, from yeast to human. The types of damage detected encompass DNA …
Genotoxicity of nanomaterials: Advanced in vitro models and high throughput methods for human hazard assessment—A review
Y Kohl, E Rundén-Pran, E Mariussen, M Hesler… - Nanomaterials, 2020 - mdpi.com
Changes in the genetic material can lead to serious human health defects, as mutations in
somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic …
somatic cells may cause cancer and can contribute to other chronic diseases. Genotoxic …
In vivo and in vitro models of hepatocellular carcinoma: current strategies for translational modeling
Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …
Sex difference in liver diseases: How preclinical models help to dissect the sex-related mechanisms sustaining NAFLD and HCC
Only a few preclinical findings are confirmed in the clinic, posing a critical issue for clinical
development. Therefore, identifying the best preclinical models can help dissect molecular …
development. Therefore, identifying the best preclinical models can help dissect molecular …
Through a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism
LA Stanley, CR Wolf - Drug Metabolism Reviews, 2022 - Taylor & Francis
The pharmacokinetic and safety assessment of drug candidates is becoming increasingly
dependent upon in vitro models of hepatic metabolism and toxicity. Predominant among …
dependent upon in vitro models of hepatic metabolism and toxicity. Predominant among …
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Genotoxicity testing is critical for predicting adverse effects of pharmaceutical, industrial, and
environmental chemicals. The alkaline comet assay is an established method for detecting …
environmental chemicals. The alkaline comet assay is an established method for detecting …
Towards better prediction of xenobiotic genotoxicity: CometChip technology coupled with a 3D model of HepaRG human liver cells
Toxicology is facing a major change in the way toxicity testing is conducted by moving away
from animal experimentation towards animal-free methods. To improve the in vitro …
from animal experimentation towards animal-free methods. To improve the in vitro …