Abstract gamma-Aminobutyric acid (GABA)-mediated inhibitory neurotransmission and the
gene products involved were discovered during the mid-twentieth century. Historically …

The glycine receptor chloride channel (GlyR) is a member of the nicotinic acetylcholine
receptor family of ligand-gated ion channels. Functional receptors of this family comprise five …

The nicotinic acetylcholine receptor controls electrical signalling between nerve and muscle
cells by opening and closing a gated, membrane-spanning pore. Here we present an atomic …

The past decade has brought many advances in our understanding of GABA A receptor-
mediated ethanol action in the central nervous system. We now know that specific GABA A …

General anesthetics are essential to modern medicine, and yet a detailed understanding of
their mechanisms of action is lacking. General anesthetics were once believed to be 'drugs …

Both clinical findings and results of experiments with animal models of alcoholic hepatitis
have shown the importance of cytokine-mediated cell–cell interactions in the onset of …

Glycine is one of the most important inhibitory neurotransmitters in the spinal cord and the
brainstem, and glycinergic synapses have a well-established role in the regulation of …

Neurotransmitter receptor systems have been the focus of intensive pharmacological
research for more than 20 years for basic and applied scientific reasons, but only recently …

It is over forty years since the major neurotransmitters and their protein receptors were
identified, and over twenty years since determination of the first amino-acid sequences of the …

Abstract The vanilloid receptor-1 (VR1) is a heat-gated ion channel that is responsible for
the burning sensation elicited by capsaicin. A similar sensation is reported by patients with …