During decades, the research field of cancer metabolism was based on the Warburg effect,
described almost one century ago. Lately, the key role of mitochondria in cancer …

Anthracycline-based chemotherapy can result in the development of a cumulative and
progressively develo** cardiomyopathy. Doxorubicin is one of the most highly prescribed …

Although the development of mitochondrial therapies has largely focused on diseases
caused by mutations in mitochondrial DNA or in nuclear genes encoding mitochondrial …

Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Anthracyclines, such as doxorubicin, are effective chemotherapeutic agents for the treatment
of cancer, but their clinical use is associated with severe and potentially life-threatening …

In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress
in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to …

Abstract Doxorubicin (DOX), or Adriamycin, an anthracycline antibiotic discovered
serendipitously as a chemotherapeutic drug several decades ago, is still one of the most …

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several
risk factors promote AF, among which diabetes mellitus has emerged as one of the most …

Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …

Mitochondrial dysfunction is a hallmark of many diseases. The retrograde signaling initiated
by dysfunctional mitochondria can bring about global changes in gene expression that alters …