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Focus on fungi
Fungi play critical roles in the homeostasis of ecosystems globally and have emerged as
significant causes of an expanding repertoire of devastating diseases in plants, animals, and …
significant causes of an expanding repertoire of devastating diseases in plants, animals, and …
Interdisciplinary approaches for the discovery of novel antifungals
Pathogenic fungi are an increasing public health concern. The emergence of antifungal
resistance coupled with the scarce antifungal arsenal highlights the need for novel …
resistance coupled with the scarce antifungal arsenal highlights the need for novel …
The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence
Candida auris, a multidrug-resistant human fungal pathogen, was first identified in 2009 in
Japan. Since then, systemic C. auris infections have now been reported in more than 50 …
Japan. Since then, systemic C. auris infections have now been reported in more than 50 …
[HTML][HTML] Characterization of a New Hsp110 Inhibitor as a Potential Antifungal
C Sun, Y Li, JM Kidd, J Han, L Ding, AE May, L Zhou… - Journal of Fungi, 2024 - mdpi.com
Fungal infections present a significant global health challenge, prompting ongoing research
to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are …
to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are …
New pharmacotherapeutic strategies for drug-resistant Candida infections: a review
J Raposa, JA Vazquez - Expert Opinion on Pharmacotherapy, 2025 - Taylor & Francis
Introduction Candida species produce a wide array of infections ranging from
mucocutaneous to systemic infections. Candida albicans remains the most common species …
mucocutaneous to systemic infections. Candida albicans remains the most common species …
[HTML][HTML] Magic-angle spinning NMR spectral editing of polysaccharides in whole cells using the DREAM scheme
L Delcourte, M Berbon, M Rodriguez, K Subban… - Methods, 2024 - Elsevier
Most bacterial, plant and fungal cells possess at their surface a protective layer called the
cell wall, conferring strength, plasticity and rigidity to withstand the osmotic pressure. This …
cell wall, conferring strength, plasticity and rigidity to withstand the osmotic pressure. This …
Mutational landscape and molecular bases of echinocandin resistance
R Durand, AG Torbey, M Giguere, A Pageau, AK Dubé… - bioRxiv, 2024 - biorxiv.org
One of the front-line drug classes used to treat invasive fungal infections is echinocandins,
which target the fungal-specific beta-glucan synthase (Fks). Treatment failure due to …
which target the fungal-specific beta-glucan synthase (Fks). Treatment failure due to …
Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy
Fungal disease affects over a billion people worldwide. Naamidine A inhibits the growth of
diverse fungal pathogens through an unknown mechanism. Here, we show that the …
diverse fungal pathogens through an unknown mechanism. Here, we show that the …
Heavy Atom engineering of Ru (II) Complex based Sonosensitizers for Enhancing Antifungal Therapy
Q Li, Y Pang, S Liang, Y Jiao, S Qiu, H Chen… - Inorganic Chemistry …, 2025 - pubs.rsc.org
Despite advance on antifungal therapy in the past decade, the issues of fungal resistance
and a lack of effective treatments are still of major concern in clinical practice. Recently …
and a lack of effective treatments are still of major concern in clinical practice. Recently …
Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges
Y Gao, Z Ji, J Zhao, J Gu - Frontiers in Microbiology, 2025 - frontiersin.org
As a particularly serious condition in immunocompromised patients, fungal infections (FIs)
have increasingly become a public health problem worldwide. Mesenchymal stem cells …
have increasingly become a public health problem worldwide. Mesenchymal stem cells …