Focus on fungi

ID Iliev, GD Brown, P Bacher, SL Gaffen, J Heitman… - Cell, 2024 - cell.com
Fungi play critical roles in the homeostasis of ecosystems globally and have emerged as
significant causes of an expanding repertoire of devastating diseases in plants, animals, and …

Interdisciplinary approaches for the discovery of novel antifungals

B Yiu, N Robbins, LE Cowen - Trends in Molecular Medicine, 2024 - cell.com
Pathogenic fungi are an increasing public health concern. The emergence of antifungal
resistance coupled with the scarce antifungal arsenal highlights the need for novel …

The Candida auris Hog1 MAP kinase is essential for the colonization of murine skin and intradermal persistence

R Shivarathri, M Chauhan, A Datta, D Das, A Karuli… - mBio, 2024 - journals.asm.org
Candida auris, a multidrug-resistant human fungal pathogen, was first identified in 2009 in
Japan. Since then, systemic C. auris infections have now been reported in more than 50 …

[HTML][HTML] Characterization of a New Hsp110 Inhibitor as a Potential Antifungal

C Sun, Y Li, JM Kidd, J Han, L Ding, AE May, L Zhou… - Journal of Fungi, 2024 - mdpi.com
Fungal infections present a significant global health challenge, prompting ongoing research
to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are …

New pharmacotherapeutic strategies for drug-resistant Candida infections: a review

J Raposa, JA Vazquez - Expert Opinion on Pharmacotherapy, 2025 - Taylor & Francis
Introduction Candida species produce a wide array of infections ranging from
mucocutaneous to systemic infections. Candida albicans remains the most common species …

[HTML][HTML] Magic-angle spinning NMR spectral editing of polysaccharides in whole cells using the DREAM scheme

L Delcourte, M Berbon, M Rodriguez, K Subban… - Methods, 2024 - Elsevier
Most bacterial, plant and fungal cells possess at their surface a protective layer called the
cell wall, conferring strength, plasticity and rigidity to withstand the osmotic pressure. This …

Mutational landscape and molecular bases of echinocandin resistance

R Durand, AG Torbey, M Giguere, A Pageau, AK Dubé… - bioRxiv, 2024 - biorxiv.org
One of the front-line drug classes used to treat invasive fungal infections is echinocandins,
which target the fungal-specific beta-glucan synthase (Fks). Treatment failure due to …

Naamidine A reveals a promising zinc-binding strategy for topical antifungal therapy

E Puumala, S Nabeela, CC Thornburg… - Antimicrobial Agents …, 2024 - journals.asm.org
Fungal disease affects over a billion people worldwide. Naamidine A inhibits the growth of
diverse fungal pathogens through an unknown mechanism. Here, we show that the …

Heavy Atom engineering of Ru (II) Complex based Sonosensitizers for Enhancing Antifungal Therapy

Q Li, Y Pang, S Liang, Y Jiao, S Qiu, H Chen… - Inorganic Chemistry …, 2025 - pubs.rsc.org
Despite advance on antifungal therapy in the past decade, the issues of fungal resistance
and a lack of effective treatments are still of major concern in clinical practice. Recently …

Therapeutic potential of mesenchymal stem cells for fungal infections: mechanisms, applications, and challenges

Y Gao, Z Ji, J Zhao, J Gu - Frontiers in Microbiology, 2025 - frontiersin.org
As a particularly serious condition in immunocompromised patients, fungal infections (FIs)
have increasingly become a public health problem worldwide. Mesenchymal stem cells …