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Multicellular tumor spheroids: A convenient in vitro model for translational cancer research
In the attempts to mitigate uncertainties in the results of monolayer culture for the
identification of cancer therapeutic targets and compounds, there has been a growing …
identification of cancer therapeutic targets and compounds, there has been a growing …
Patient-specific colorectal-cancer-associated fibroblasts modulate tumor microenvironment mechanics
Cancer-associated fibroblasts (CAFs) play a major role in reorganizing the physical tumor
micro-environment and changing tissue stiffness. Herein, using an engineered three …
micro-environment and changing tissue stiffness. Herein, using an engineered three …
[HTML][HTML] Regularization techniques and inverse approaches in 3D Traction Force Microscopy
The conception of inverse methods in the context of Traction Force Microscopy (TFM) is
influenced by multiple factors, such as nonlinear effects, dimensionality (2D/3D), and …
influenced by multiple factors, such as nonlinear effects, dimensionality (2D/3D), and …
Mechanical signatures in cancer metastasis
The cancer metastatic cascade includes a series of mechanical barrier-crossing events,
involving the physical movement of cancer cells from their primary location to a distant …
involving the physical movement of cancer cells from their primary location to a distant …
Controlling cellular packing and hypoxia in 3D tumor spheroids via DNA interactions
SA Saemundsson, SD Curry, BM Bower… - Biomaterials …, 2024 - pubs.rsc.org
Tumor spheroids represent valuable in vitro models for studying cancer biology and
evaluating therapeutic strategies. In this study, we investigated the impact of varying lengths …
evaluating therapeutic strategies. In this study, we investigated the impact of varying lengths …