Serving as the basis of cell life, interactions between nucleic acids and proteins play
essential roles in fundamental cellular processes. Aptamers are unique single-stranded …

Nucleic acid aptamers are oligonucleotide sequences screened by an in vitro methodology
called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Known as …

The classical DNA aptamer for adenosine and ATP has been the most used small molecule
binding aptamer for biosensing, imaging, and DNA nanotechnology. This sequence has …

The 26-mer DNA aptamer (AF26) that specifically binds aflatoxin B1 (AFB1) with nM-level
high affinity is rare among hundreds of aptamers for small molecules. Despite its predicted …

Aptamers are nucleic acid-based affinity reagents that have been incorporated into a variety
of molecular sensor formats. However, many aptamer sensors exhibit insufficient sensitivity …

Aptamers are nucleic acid bioreceptors that have been widely utilized for a variety of
biosensing applications, including in vivo detection methods that would not be possible with …

The classical DNA aptamer for adenosine and ATP was selected twice using ATP as the
target in 1995 and 2005, respectively. In 2022, this motif appeared four more times from …

The RNA molecule plays a pivotal role in many biological processes by relaying genetic
information, regulating gene expression, and serving as molecular machines and catalyzers …

The simultaneous evolution of multiple aptamers can drastically increase the speed of
aptamer discovery. Most previous studies used the same concentration for different targets …

The field of nucleic acid therapeutics has witnessed a significant surge in recent times, as
evidenced by the increasing number of approved genetic drugs. However, current platform …