Vinca alkaloids have been approved as anticancer drugs for more than 50 years. They have
been classified as cytotoxic chemotherapy drugs that act during cellular mitosis, enabling …

Mitotic catastrophe, as defined in 2012 by the International Nomenclature Committee on Cell
Death, is a bona fide intrinsic oncosuppressive mechanism that senses mitotic failure and …

Abstract m5C is one of the longest-known RNA modifications, however, its developmental
dynamics, functions, and evolution in mRNAs remain largely unknown. Here, we generate …

Dysregulation of cell cycle progression is a hallmark of cancer cells. In recent years, efforts
have been devoted to the development of new therapies that target proteins involved in cell …

PM2. 5 negatively affects human health, particularly lung injury. However, the role of PM2. 5-
regulated miRNAs in lung injury remains unknown. MiRNA array results showed mmu-miR …

Anti-tubulin agents constitute a large class of compounds with broad activity both in solid
tumors and hematologic malignancies, due to the interference with microtubule dynamics …

Natural products are a major source of anticancer agents and play critical roles in anticancer
drug development. Inspired by the complexity-to-diversity strategy, novel …

Interfering with mitosis for cancer treatment is an old concept that has proven highly
successful in the clinics. Microtubule poisons are used to treat patients with different types of …

Cells experiencing delays in mitotic progression are prone to undergo apoptosis unless they
can exit mitosis before proapoptotic factors reach a critical threshold. Microtubule targeting …

Background: The microtubule assembly inhibitor nocodazole has been shown to trigger
caspase-independent mitotic death and caspase dependent apoptosis. Similar to apoptosis …