Herpesvirus late gene expression: a viral-specific pre-initiation complex is key
H Gruffat, R Marchione, E Manet - Frontiers in microbiology, 2016 - frontiersin.org
During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of
gene expression that can be divided into three general stages: immediate-early (IE), early …
gene expression that can be divided into three general stages: immediate-early (IE), early …
Better late than never: A unique strategy for late gene transcription in the beta-and gammaherpesviruses
During lytic replication, herpesviruses express their genes in a temporal cascade
culminating in expression of “late” genes. Two subfamilies of herpesviruses, the beta-and …
culminating in expression of “late” genes. Two subfamilies of herpesviruses, the beta-and …
Epstein-Barr virus late gene transcription depends on the assembly of a virus-specific preinitiation complex
V Aubry, F Mure, B Mariamé, T Deschamps… - Journal of …, 2014 - Am Soc Microbiol
During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of
gene expression that has three general stages: immediate early (IE), early (E), and late (L) …
gene expression that has three general stages: immediate early (IE), early (E), and late (L) …
Cytomegalovirus late transcription factor target sequence diversity orchestrates viral early to late transcription
Beta-and gammaherpesviruses late transcription factors (LTFs) target viral promoters
containing a TATT sequence to drive transcription after viral DNA replication has begun …
containing a TATT sequence to drive transcription after viral DNA replication has begun …
Repression of viral gene expression and replication by the unfolded protein response effector XBP1u
The unfolded protein response (UPR) is a cellular homeostatic circuit regulating protein
synthesis and processing in the ER by three ER-to-nucleus signaling pathways. One …
synthesis and processing in the ER by three ER-to-nucleus signaling pathways. One …
Kaposi's sarcoma-associated herpesvirus ORF18 and ORF30 are essential for late gene expression during lytic replication
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with several human
malignances. As saliva is likely the major vehicle for KSHV transmission, we studied in vitro …
malignances. As saliva is likely the major vehicle for KSHV transmission, we studied in vitro …
Transcription of true late (γ2) cytomegalovirus genes requires UL92 function that is conserved among beta-and gammaherpesviruses
S Omoto, ES Mocarski - Journal of virology, 2014 - Am Soc Microbiol
Human cytomegalovirus-encoded UL92 plays an essential role in viral replication that has
not been resolved. We show here that this gene controls the accumulation of true late (γ2) …
not been resolved. We show here that this gene controls the accumulation of true late (γ2) …
Human cytomegalovirus pUL79 is an elongation factor of RNA polymerase II for viral gene transcription
YC Perng, JA Campbell, DJ Lenschow, D Yu - PLoS pathogens, 2014 - journals.plos.org
In this study, we have identified a unique mechanism in which human cytomegalovirus
(HCMV) protein pUL79 acts as an elongation factor to direct cellular RNA polymerase II for …
(HCMV) protein pUL79 acts as an elongation factor to direct cellular RNA polymerase II for …
Decoding murine cytomegalovirus
The genomes of both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV)
were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially …
were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially …
Association of Kaposi's sarcoma-associated herpesvirus ORF31 with ORF34 and ORF24 is critical for late gene expression
Transcription of herpesvirus late genes depends on several virus-encoded proteins whose
function is not completely understood. Here, we identify a viral trimeric complex of Kaposi's …
function is not completely understood. Here, we identify a viral trimeric complex of Kaposi's …