Sp1 and the 'hallmarks of cancer'
K Beishline, J Azizkhan‐Clifford - The FEBS journal, 2015 - Wiley Online Library
For many years, transcription factor Sp1 was viewed as a basal transcription factor and
relegated to a role in the regulation of so‐called housekee** genes. Identification of Sp1's …
relegated to a role in the regulation of so‐called housekee** genes. Identification of Sp1's …
Mammalian Krüppel-like factors in health and diseases
The Krüppel-like factor (KLF) family of transcription factors regulates diverse biological
processes that include proliferation, differentiation, growth, development, survival, and …
processes that include proliferation, differentiation, growth, development, survival, and …
Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding
Abstract β-hemoglobinopathies such as sickle cell disease (SCD) and β-thalassemia result
from mutations in the adult HBB (β-globin) gene. Reactivating the developmentally silenced …
from mutations in the adult HBB (β-globin) gene. Reactivating the developmentally silenced …
Sp1 and krüppel‐like factor family of transcription factors in cell growth regulation and cancer
AR Black, JD Black… - Journal of cellular …, 2001 - Wiley Online Library
The Sp/KLF family contains at least twenty identi® ed members which include Sp1-4 and
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …
numerous kruÈppel-like factors. Members of the family bind with varying af® nities to …
Gene regulatory programs conferring phenotypic identities to human NK cells
Natural killer (NK) cells develop from common progenitors but diverge into distinct subsets,
which differ in cytokine production, cytotoxicity, homing, and memory traits. Given their …
which differ in cytokine production, cytotoxicity, homing, and memory traits. Given their …
Krüppel-like factors: three fingers in many pies
JJ Bieker - Journal of Biological Chemistry, 2001 - ASBMB
Krüppel-like factors (KLFs) 1 are DNA-binding transcriptional regulators that play diverse
roles during differentiation and development. They form a subset of the broad class of …
roles during differentiation and development. They form a subset of the broad class of …
[HTML][HTML] The biology of the mammalian Krüppel-like family of transcription factors
Recent advances in molecular cloning have led to the identification of a large number of
mammalian zinc finger-containing transcription factors that exhibit homology to the …
mammalian zinc finger-containing transcription factors that exhibit homology to the …
Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation
Transcription factor Sp1 has been implicated in the expression of many genes. Moreover, it
has been suggested that Sp1 is linked to the maintenance of methylation-free CpG islands …
has been suggested that Sp1 is linked to the maintenance of methylation-free CpG islands …
A tale of three fingers: the family of mammalian Sp/XKLF transcription factors
S Philipsen, G Suske - Nucleic acids research, 1999 - academic.oup.com
One of the most common regulatory elements is the GC box and the related GT/CACC box,
which are widely distributed in promoters, enhancers and locus control regions of …
which are widely distributed in promoters, enhancers and locus control regions of …
The Kruppel‐like factor KLF4 is a critical regulator of monocyte differentiation
MW Feinberg, AK Wara, Z Cao, MA Lebedeva… - The EMBO …, 2007 - embopress.org
Monocyte differentiation involves the participation of lineage‐restricted transcription factors,
although the mechanisms by which this process occurs are incompletely defined. Within the …
although the mechanisms by which this process occurs are incompletely defined. Within the …