Small molecule-based targeting of chromatin regulatory factors has emerged as a promising
therapeutic strategy in recent years. The development and ongoing clinical evaluation of …

Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …

Exosomes are nano-sized vesicles produced by healthy and virus-infected cells. Exosomes
derived from infected cells have been shown to contain viral microRNAs (miRNAs). HIV-1 …

HIV-1/AIDS remains a global public health problem. The world health organization (WHO)
reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which …

Thirty-five years after the identification of HIV-1 as the causative agent of AIDS, we are still in
search of vaccines and treatments to eradicate this devastating infectious disease. Progress …

BET proteins commonly activate cellular gene expression, yet inhibiting their recruitment
paradoxically reactivates latent HIV-1 transcription. Here we identify the short isoform of BET …

Persistence of a reservoir of latently infected memory T cells provides a barrier to HIV
eradication in treated patients. Several reports have implicated the involvement of SWI/SNF …

Three decades of extensive work in the HIV field have revealed key viral and host cell
factors controlling proviral transcription. Various models of transcriptional regulation have …

Current antiretroviral therapy (ART) increases the survival of HIV-infected individuals, yet it is
not curative. The major barrier to finding a definitive cure for HIV is our inability to identify …

Background Transcription from the integrated HIV-1 promoter is directly governed by its
chromatin environment, and the nucleosome-1 downstream from the transcription start site …