Clerodane diterpenes: sources, structures, and biological activities
R Li, SL Morris-Natschke, KH Lee - Natural product reports, 2016 - pubs.rsc.org
Covering: 1990 to 2015 The clerodane diterpenoids are a widespread class of secondary
metabolites and have been found in several hundreds of plant species from various families …
metabolites and have been found in several hundreds of plant species from various families …
Strategies to discover unexpected targets for drugs active at G protein–coupled receptors
G protein–coupled receptors (GPCRs) are an evolutionarily conserved family of signaling
molecules comprising approximately 2% of the human genome; this receptor family remains …
molecules comprising approximately 2% of the human genome; this receptor family remains …
Natural products for the treatment of pain: chemistry and pharmacology of salvinorin A, mitragynine, and collybolide
S Chakraborty, S Majumdar - Biochemistry, 2020 - ACS Publications
Pain remains a very pervasive problem throughout medicine. Classical pain management is
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …
From plant to chemistry: Sources of active opioid antinociceptive principles for medicinal chemistry and drug design
R Turnaturi, S Piana, S Spoto, G Costanzo, L Reina… - Molecules, 2023 - mdpi.com
Pain continues to be an enormous global health challenge, with millions of new untreated or
inadequately treated patients reported annually. With respect to current clinical applications …
inadequately treated patients reported annually. With respect to current clinical applications …
Neuropharmacology of the naturally occurring κ-opioid hallucinogen salvinorin A
Salvia divinorum is a perennial sage native to Oaxaca, Mexico, that has been used
traditionally in divination rituals and as a treatment for the “semimagical” disease panzón de …
traditionally in divination rituals and as a treatment for the “semimagical” disease panzón de …
Kappa opioids and the modulation of pain
Background and rationale Pain is a complex sensory experience, involving cognitive factors,
environment (setting, society, and culture), experience, and gender and is modulated …
environment (setting, society, and culture), experience, and gender and is modulated …
Endogenous opiates and behavior: 2006
RJ Bodnar - Peptides, 2007 - Elsevier
This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …
Clerodane furanoditerpenoids from the stems of Tinospora sinensis
JS Zhang, DF Xu, YY Wang, RF Ma… - Archives of pharmacal …, 2022 - Springer
One new clerodane-type furanoditerpenoid tinosinoid A (1) and nine new nor-clerodane
analogs tinosinoids B–J (2− 10) have been isolated from the stems of Tinospora sinensis …
analogs tinosinoids B–J (2− 10) have been isolated from the stems of Tinospora sinensis …
Pharmacokinetics and Pharmacodynamics of Salvinorin A and Salvia divinorum: Clinical and Forensic Aspects
Salvia divinorum Epling and Játiva is a perennial mint from the Lamiaceae family, endemic
to Mexico, predominantly from the state of Oaxaca. Due to its psychoactive properties, S …
to Mexico, predominantly from the state of Oaxaca. Due to its psychoactive properties, S …
Salvinorin A analogs as probes in opioid pharmacology
The opium poppy, PapaVer somniferum, is one of several plants that have profoundly
affected human history. 1 It has provided an unmatched medicine for the relief of pain for …
affected human history. 1 It has provided an unmatched medicine for the relief of pain for …