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Cell-based in vitro models for predicting drug permeability
Introduction: In vitro cell models have been used to predict drug permeation in early stages
of drug development, since they represent an easy and reproducible method, allowing the …
of drug development, since they represent an easy and reproducible method, allowing the …
Application of standard cell cultures and 3D in vitro tissue models as an effective tool in drug design and development
Cell culture systems are essential tools used in a wide range of biomedical and clinical
studies. Two dimensional cell culture models (2D) provide basic information on cytotoxicity …
studies. Two dimensional cell culture models (2D) provide basic information on cytotoxicity …
The role of mucus in cell-based models used to screen mucosal drug delivery
The increasing interest in develo** tools to predict drug absorption through mucosal
surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro …
surfaces is fostering the establishment of epithelial cell-based models. Cell-based in vitro …
Studies and methodologies on vaginal drug permeation
The vagina stands as an important alternative to the oral route for those systemic drugs that
are poorly absorbed orally or are rapidly metabolized by the liver. Drug permeation through …
are poorly absorbed orally or are rapidly metabolized by the liver. Drug permeation through …
Vaginal drug delivery: strategies and concerns in polymeric nanoparticle development
Introduction: Vaginal infection is widespread and> 80% of females encounter such infections
during their lives. Topical treatment and prevention of vaginal infection allows direct …
during their lives. Topical treatment and prevention of vaginal infection allows direct …
Characterization of a hormone-responsive organotypic human vaginal tissue model: morphologic and immunologic effects
S Ayehunie, A Islam, C Cannon… - Reproductive …, 2015 - journals.sagepub.com
Estrogen and progesterone regulate proliferation and differentiation of epithelial cells in the
female genital tract. We investigated the effects of these hormones on reconstructed human …
female genital tract. We investigated the effects of these hormones on reconstructed human …
Vaginal irritation testing—prospects of human organotypic vaginal tissue culture models
S Ayehunie, T Landry, A Armento - In Vitro Cellular & Developmental …, 2024 - Springer
Personal lubricants intended for local or systemic delivery via the vaginal route can induce
vaginal irritation, damage the vaginal epithelial barrier which can enhance microbial entry …
vaginal irritation, damage the vaginal epithelial barrier which can enhance microbial entry …
Devices and methods for intraluminal retention and drug delivery
Retention devices and methods are provided for drug deliv ery. The device may include a
housing configured for intraluminal deployment into a human or animal subject and at least …
housing configured for intraluminal deployment into a human or animal subject and at least …
An automated system for cattle reproductive management under the IoT framework. Part II: induction of luteinizing hormone release after gonadotropin releasing …
Technologies for automating animal management and monitoring tasks can improve
efficiency and productivity of livestock production. We developed the e-Synch system for …
efficiency and productivity of livestock production. We developed the e-Synch system for …
[HTML][HTML] Intravaginal instillation of gonadotropin-releasing hormone analogues with an absorption enhancer induced a surge of luteinizing hormone in lactating dairy …
Our objectives were to evaluate circulating LH concentrations after intravaginal (IVG)
instillation of GnRH analogs in lactating dairy cows. In 2 experiments, lactating Holstein …
instillation of GnRH analogs in lactating dairy cows. In 2 experiments, lactating Holstein …