Reactive oxygen species (ROS) are continuously generated within living systems and the
inability to manage ROS load leads to elevated oxidative stress and cell damage. Oxidative …

Abstract Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the
detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating …

A family of detoxifying enzymes called aldehyde dehydrogenases (ALDHs) has been a
subject of recent interest, as its role in detoxifying aldehydes that accumulate through …

Background: Aldehydes are highly reactive molecules. While several non-P450 enzyme
systems participate in their metabolism, one of the most important is the aldehyde …

Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric
oxide (NO). Impaired bioavailability and/or responsiveness to endogenous NO has been …

Mitochondrial aldehyde dehydrogenase (ALDH2) is one of the most important enzymes in
human alcohol metabolism. The oriental ALDH2* 504Lys variant functions as a dominant …

In this review, novel aspects of the role of esterases, which contribute to the metabolism of
10% of therapeutic drugs, are described. Esterases hydrolyze the compounds that contain …

Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide
dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator …

In approximately one billion people, a point mutation inactivates a key detoxifying enzyme,
aldehyde dehydrogenase (ALDH2). This mitochondrial enzyme metabolizes toxic biogenic …

Numerous conditions promote oxidative stress, leading to the build-up of reactive aldehydes
that cause cell damage and contribute to cardiac diseases. Aldehyde dehydrogenases …