Engineering precise sequence-defined polymers for advanced functions

Q Shi, Z Deng, M Hou, X Hu, S Liu - Progress in Polymer Science, 2023 - Elsevier
Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

Precision Sequence‐Defined Polymers: From Sequencing to Biological Functions

Q Shi, Z Zhang, S Liu - Angewandte Chemie International …, 2024 - Wiley Online Library
Precise sequence‐defined polymers (SDPs) with uniform chain‐to‐chain structure including
chain length, unit sequence, and end functionalities represent the pinnacle of sophistication …

Controlled noncovalent synthesis of secondary supramolecular polymers

S Sarkar, R Laishram, D Deb… - Journal of the American …, 2023 - ACS Publications
Dynamic supramolecular polymers, with their functional similarities to classical covalent
polymers and their adaptive and self-repairing nature reminiscent of biological assemblies …

Expanding the architectural horizon of nucleic-acid-polymer biohybrids by site-controlled incorporation of ATRP initiators in DNA and RNA

J Jeong, G Szczepaniak, SR Das, K Matyjaszewski - Chem, 2023 - cell.com
Modifying biomacromolecules with synthetic polymers has been a powerful approach to
develo** multifunctional hybrid biomaterials for nanoscience and biomedical applications …

Controlled Self‐Assembly of Discrete Amphiphilic Oligourethanes with a Cascade Self‐Immolative Motif

J Xu, C Lv, Q Shi, J Zhang, N Wang… - Angewandte Chemie …, 2023 - Wiley Online Library
Discrete polymers offer an excellent platform for comprehending the interplay between
precise chain structures, distinctive self‐assembly behavior, and functional applications …

DNA-Mediated Peptide Assembly into Protein Mimics

F Zhao, M Frandsen, S Capodaglio… - Journal of the American …, 2024 - ACS Publications
The design of new protein structures is challenging due to their vast sequence space and
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …

Noncanonical condensation of nucleic acid chains by hydrophobic gold nanocrystals

Y Li, H Zheng, H Lu, M Duan, C Li, M Li, J Li, L Wang… - JACS Au, 2023 - ACS Publications
Nucleic acid condensates are essential for various biological processes and have numerous
applications in nucleic acid nanotechnology, gene therapy, and mRNA vaccines. However …

Controlled fabrication of uniform digital nanorods from precise sequence-defined amphiphilic polymers in aqueous media

QQ Shi, X Zhou, J Xu, N Wang, JL Zhang, XL Hu… - Chinese Journal of …, 2023 - Springer
Compared with spherical micelles, rod/worm-like micelles not only have extended blood
circulation duration, but also exhibit favorable cellular uptake behavior, which is promising …

DNA Volume, Topology, and Flexibility Dictate Nanopore Current Signals

Y Li, SE Sandler, UF Keyser, J Zhu - Nano Letters, 2023 - ACS Publications
Nanopores have developed into powerful single-molecule sensors capable of identifying
and characterizing small polymers, such as DNA, by electrophoretically driving them through …

Towards rational design: Develo** universal freezing routes for anchoring DNA onto gold nanoparticles

X Wang, Z Yang, Y Li, K Huang, N Cheng - Journal of Colloid and Interface …, 2024 - Elsevier
DNA-functionalized gold nanoparticles (AuNPs), also known as spherical nucleic acids, are
widely used in the development of biosensors, resulting in anchoring DNA onto AuNPs …