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Engineering precise sequence-defined polymers for advanced functions
Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …
Precision Sequence‐Defined Polymers: From Sequencing to Biological Functions
Precise sequence‐defined polymers (SDPs) with uniform chain‐to‐chain structure including
chain length, unit sequence, and end functionalities represent the pinnacle of sophistication …
chain length, unit sequence, and end functionalities represent the pinnacle of sophistication …
Controlled noncovalent synthesis of secondary supramolecular polymers
Dynamic supramolecular polymers, with their functional similarities to classical covalent
polymers and their adaptive and self-repairing nature reminiscent of biological assemblies …
polymers and their adaptive and self-repairing nature reminiscent of biological assemblies …
Expanding the architectural horizon of nucleic-acid-polymer biohybrids by site-controlled incorporation of ATRP initiators in DNA and RNA
Modifying biomacromolecules with synthetic polymers has been a powerful approach to
develo** multifunctional hybrid biomaterials for nanoscience and biomedical applications …
develo** multifunctional hybrid biomaterials for nanoscience and biomedical applications …
Controlled Self‐Assembly of Discrete Amphiphilic Oligourethanes with a Cascade Self‐Immolative Motif
Discrete polymers offer an excellent platform for comprehending the interplay between
precise chain structures, distinctive self‐assembly behavior, and functional applications …
precise chain structures, distinctive self‐assembly behavior, and functional applications …
DNA-Mediated Peptide Assembly into Protein Mimics
F Zhao, M Frandsen, S Capodaglio… - Journal of the American …, 2024 - ACS Publications
The design of new protein structures is challenging due to their vast sequence space and
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …
Noncanonical condensation of nucleic acid chains by hydrophobic gold nanocrystals
Nucleic acid condensates are essential for various biological processes and have numerous
applications in nucleic acid nanotechnology, gene therapy, and mRNA vaccines. However …
applications in nucleic acid nanotechnology, gene therapy, and mRNA vaccines. However …
Controlled fabrication of uniform digital nanorods from precise sequence-defined amphiphilic polymers in aqueous media
Compared with spherical micelles, rod/worm-like micelles not only have extended blood
circulation duration, but also exhibit favorable cellular uptake behavior, which is promising …
circulation duration, but also exhibit favorable cellular uptake behavior, which is promising …
DNA Volume, Topology, and Flexibility Dictate Nanopore Current Signals
Nanopores have developed into powerful single-molecule sensors capable of identifying
and characterizing small polymers, such as DNA, by electrophoretically driving them through …
and characterizing small polymers, such as DNA, by electrophoretically driving them through …
Towards rational design: Develo** universal freezing routes for anchoring DNA onto gold nanoparticles
X Wang, Z Yang, Y Li, K Huang, N Cheng - Journal of Colloid and Interface …, 2024 - Elsevier
DNA-functionalized gold nanoparticles (AuNPs), also known as spherical nucleic acids, are
widely used in the development of biosensors, resulting in anchoring DNA onto AuNPs …
widely used in the development of biosensors, resulting in anchoring DNA onto AuNPs …