Engineering precise sequence-defined polymers for advanced functions

Q Shi, Z Deng, M Hou, X Hu, S Liu - Progress in Polymer Science, 2023 - Elsevier
Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …

Precision Sequence‐Defined Polymers: From Sequencing to Biological Functions

Q Shi, Z Zhang, S Liu - Angewandte Chemie, 2024 - Wiley Online Library
Precise sequence‐defined polymers (SDPs) with uniform chain‐to‐chain structure including
chain length, unit sequence, and end functionalities represent the pinnacle of sophistication …

Controlled noncovalent synthesis of secondary supramolecular polymers

S Sarkar, R Laishram, D Deb… - Journal of the American …, 2023 - ACS Publications
Dynamic supramolecular polymers, with their functional similarities to classical covalent
polymers and their adaptive and self-repairing nature reminiscent of biological assemblies …

Heat-activated growth of metastable and length-defined DNA fibers expands traditional polymer assembly

MD Dore, MG Rafique, TP Yang, M Zorman… - Nature …, 2024 - nature.com
Biopolymers such as nucleic acids and proteins exhibit dynamic backbone folding, wherein
site-specific intramolecular interactions determine overall structure. Proteins then …

Controlled Self‐Assembly of Discrete Amphiphilic Oligourethanes with a Cascade Self‐Immolative Motif

J Xu, C Lv, Q Shi, J Zhang, N Wang… - Angewandte Chemie …, 2023 - Wiley Online Library
Discrete polymers offer an excellent platform for comprehending the interplay between
precise chain structures, distinctive self‐assembly behavior, and functional applications …

DNA-mediated peptide assembly into protein mimics

F Zhao, M Frandsen, S Capodaglio… - Journal of the American …, 2024 - ACS Publications
The design of new protein structures is challenging due to their vast sequence space and
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …

Controlled fabrication of uniform digital nanorods from precise sequence-defined amphiphilic polymers in aqueous media

QQ Shi, X Zhou, J Xu, N Wang, JL Zhang, XL Hu… - Chinese Journal of …, 2023 - Springer
Compared with spherical micelles, rod/worm-like micelles not only have extended blood
circulation duration, but also exhibit favorable cellular uptake behavior, which is promising …

Extracellular Vesicle Spherical Nucleic Acids

H Chen, Q Ding, L Li, P Wei, Z Niu, T Kong, P Fu… - JACS Au, 2024 - ACS Publications
Extracellular vesicles (EVs) are naturally occurring vesicles secreted by cells that can
transport cargo between cells, making them promising bioactive nanomaterials. However …