Engineering precise sequence-defined polymers for advanced functions
Unlike natural macromolecules (eg, nucleic acids and proteins) possessing precisely
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …
defined molar mass, chain sequence, chirality, and topology, synthetic polymers are typically …
Precision Sequence‐Defined Polymers: From Sequencing to Biological Functions
Precise sequence‐defined polymers (SDPs) with uniform chain‐to‐chain structure including
chain length, unit sequence, and end functionalities represent the pinnacle of sophistication …
chain length, unit sequence, and end functionalities represent the pinnacle of sophistication …
Controlled noncovalent synthesis of secondary supramolecular polymers
Dynamic supramolecular polymers, with their functional similarities to classical covalent
polymers and their adaptive and self-repairing nature reminiscent of biological assemblies …
polymers and their adaptive and self-repairing nature reminiscent of biological assemblies …
Heat-activated growth of metastable and length-defined DNA fibers expands traditional polymer assembly
Biopolymers such as nucleic acids and proteins exhibit dynamic backbone folding, wherein
site-specific intramolecular interactions determine overall structure. Proteins then …
site-specific intramolecular interactions determine overall structure. Proteins then …
Self‐Assembled DNA Nanospheres Driven by Carbon Dots for MicroRNAs Imaging in Tumor via Logic Circuit
Q Chen, X ** multifunctional hybrid biomaterials for nanoscience and biomedical applications …
Controlled Self‐Assembly of Discrete Amphiphilic Oligourethanes with a Cascade Self‐Immolative Motif
Discrete polymers offer an excellent platform for comprehending the interplay between
precise chain structures, distinctive self‐assembly behavior, and functional applications …
precise chain structures, distinctive self‐assembly behavior, and functional applications …
DNA-mediated peptide assembly into protein mimics
F Zhao, M Frandsen, S Capodaglio… - Journal of the American …, 2024 - ACS Publications
The design of new protein structures is challenging due to their vast sequence space and
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …
the complexity of protein folding. Here, we report a new modular DNA-templated strategy to …
Controlled fabrication of uniform digital nanorods from precise sequence-defined amphiphilic polymers in aqueous media
Compared with spherical micelles, rod/worm-like micelles not only have extended blood
circulation duration, but also exhibit favorable cellular uptake behavior, which is promising …
circulation duration, but also exhibit favorable cellular uptake behavior, which is promising …
Extracellular Vesicle Spherical Nucleic Acids
H Chen, Q Ding, L Li, P Wei, Z Niu, T Kong, P Fu… - JACS Au, 2024 - ACS Publications
Extracellular vesicles (EVs) are naturally occurring vesicles secreted by cells that can
transport cargo between cells, making them promising bioactive nanomaterials. However …
transport cargo between cells, making them promising bioactive nanomaterials. However …